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    Dnajc2 DnaJ heat shock protein family (Hsp40) member C2 [ Mus musculus (house mouse) ]

    Gene ID: 22791, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnajc2provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C2provided by MGI
    Primary source
    MGI:MGI:99470
    See related
    Ensembl:ENSMUSG00000029014 AllianceGenome:MGI:99470
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zrf1; Zrf2; MIDA1
    Summary
    Predicted to enable several functions, including Hsp70 protein binding activity; ribosome binding activity; and ubiquitin-modified histone reader activity. Acts upstream of or within DNA replication and negative regulation of DNA biosynthetic process. Predicted to be located in cytoplasm; nuclear membrane; and nucleolus. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; blastocyst; brain; hemolymphoid system gland; and reproductive system. Orthologous to human DNAJC2 (DnaJ heat shock protein family (Hsp40) member C2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 20.3), CNS E11.5 (RPKM 19.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnajc2 in Genome Data Viewer
    Location:
    5 A3; 5 9.97 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (21962279..21990183, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (21757266..21785264, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1463 Neighboring gene STARR-positive B cell enhancer ABC_E11721 Neighboring gene predicted gene, 54323 Neighboring gene STARR-seq mESC enhancer starr_12576 Neighboring gene peptidase (mitochondrial processing) beta Neighboring gene predicted gene 15715 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase 2 Neighboring gene solute carrier family 26, member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reporter gene stimulation by MIDA1 through its DnaJ homology region. Yoshida M, et al. Biochem Biophys Res Commun, 2004 Nov 5. PMID 15465022
    2. DNAJC2 is required for mouse early embryonic development. Helary L, et al. Biochem Biophys Res Commun, 2019 Aug 13. PMID 31230751
    3. Zrf1 controls mesoderm lineage genes and cardiomyocyte differentiation. Kaymak A, et al. Cell Cycle, 2016 Dec. PMID 27754813, Free PMC Article
    4. MIDA1, a protein associated with Id, regulates cell growth. Shoji W, et al. J Biol Chem, 1995 Oct 20. PMID 7559602
    5. Cloning and chromosomal localization of a mouse cDNA with homology to the Saccharomyces cerevisiae gene zuotin. Hughes R, et al. Genomics, 1995 Sep 20. PMID 8666407

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Invalidation of DNAJC2 leads to early post-implantation lethality of mouse embryos. Dnajc2 is expressed throughout early mouse embryogenesis. Maternal Dnajc2 mRNAs allow early preimplantation mouse embryonic development.
      Title: DNAJC2 is required for mouse early embryonic development.
    2. These findings reveal a mechanism by which nutrient sensing pathways impact on cell senescence through the activation of mTORC1-S6 kinases and the phosphorylation of ZRF1.
      Title: ZRF1 is a novel S6 kinase substrate that drives the senescence programme.
    3. Zrf1 is identified as a novel regulator of the mesodermal lineage that might facilitate spatiotemporal expression of genes.
      Title: Zrf1 controls mesoderm lineage genes and cardiomyocyte differentiation.
    4. Data suggest involvement of MIDA1 in the stimulation of transcription in concert with Hsp70/Hsc70 molecular chaperones.
      Title: Reporter gene stimulation by MIDA1 through its DnaJ homology region.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-modified histone reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-modified histone reader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' cotranslational protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' cotranslational protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 2
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 2
    Id associate 1
    zuotin related factor 2
    zuotin-related factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417606.1 → NP_001404535.1  dnaJ homolog subfamily C member 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125313
      UniProtKB/TrEMBL
      E9Q9H2, E9Q9H3
      Related
      ENSMUSP00000110849.2, ENSMUST00000115195.8

    2. NM_001417607.1 → NP_001404536.1  dnaJ homolog subfamily C member 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC125313
      UniProtKB/TrEMBL
      Q3TRX6
      Related
      ENSMUST00000147987.2

    3. NM_001417608.1 → NP_001404537.1  dnaJ homolog subfamily C member 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC125313

    4. NM_009584.5 → NP_033610.1  dnaJ homolog subfamily C member 2 isoform 1

      See identical proteins and their annotated locations for NP_033610.1

      Status: VALIDATED

      Source sequence(s)
      AC125313
      Consensus CDS
      CCDS19107.1
      UniProtKB/Swiss-Prot
      P54103, Q61866
      UniProtKB/TrEMBL
      E9Q9H3
      Related
      ENSMUSP00000030771.6, ENSMUST00000030771.12
      Conserved Domains (5) summary
      smart00717
      Location:552 → 602
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      COG5269
      Location:75 → 368
      ZUO1; Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]
      cd00167
      Location:553 → 600
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00226
      Location:88 → 158
      DnaJ; DnaJ domain
      pfam16717
      Location:349 → 420
      RAC_head; Ribosome-associated complex head domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      21962279..21990183 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54103.2 GenPept UniProtKB/Swiss-Prot:P54103

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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