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    Nkiras1 NFKB inhibitor interacting Ras-like protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 69721, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nkiras1provided by MGI
    Official Full Name
    NFKB inhibitor interacting Ras-like protein 1provided by MGI
    Primary source
    MGI:MGI:1916971
    See related
    Ensembl:ENSMUSG00000021772 AllianceGenome:MGI:1916971
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KBRAS1; kappaB-Ras1; 2400004O09Rik
    Summary
    Enables GTPase activating protein binding activity. Acts upstream of or within several processes, including Ral protein signal transduction; lung alveolus development; and surfactant homeostasis. Predicted to be located in cytosol and endoplasmic reticulum. Orthologous to human NKIRAS1 (NFKB inhibitor interacting Ras like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 13.7), cerebellum adult (RPKM 13.3) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nkiras1 in Genome Data Viewer
    Location:
    14 A1; 14 7.08 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (4185693..4198560, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (18271136..18284003)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22350 Neighboring gene STARR-seq mESC enhancer starr_36051 Neighboring gene STARR-seq mESC enhancer starr_36050 Neighboring gene ubiquitin-conjugating enzyme E2E 1 Neighboring gene predicted gene, 41098 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:19103554-19103663 Neighboring gene ribosomal protein L15 Neighboring gene predicted gene 7084

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis. Beel S, et al. Nat Commun, 2020 Jul 8. PMID 32641778, Free PMC Article
    2. A pan-cancer analysis implicates human NKIRAS1 as a tumor-suppressor gene. Postler TS, et al. Proc Natl Acad Sci U S A, 2023 Nov 14. PMID 37931099, Free PMC Article
    3. Site-specific gene targeting in mouse embryonic stem cells with intact bacterial artificial chromosomes. Yang Y, et al. Nat Biotechnol, 2003 Apr. PMID 12627171
    4. RelA/p65 regulation of IkappaBbeta. Hertlein E, et al. Mol Cell Biol, 2005 Jun. PMID 15923614, Free PMC Article
    5. A subclass of Ras proteins that regulate the degradation of IkappaB. Fenwick C, et al. Science, 2000 Feb 4. PMID 10657303

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activating protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activating protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ral protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Ral protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lung alveolus development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of tumor necrosis factor-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within surfactant homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NF-kappa-B inhibitor-interacting Ras-like protein 1
    Names
    I-kappa-B-interacting Ras-like protein 1
    kappa B-Ras protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316711.1 → NP_001303640.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in its 5' UTR and coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC154489, AK010285, AK028539, AW490494, BC054390, BY332128
      UniProtKB/Swiss-Prot
      Q8CEC5
      Conserved Domains (1) summary
      cl38936
      Location:8 → 138
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001316712.1 → NP_001303641.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC154489, AK028539, AW490494, BC054390, BY114837, BY332128
      UniProtKB/Swiss-Prot
      Q8CEC5
      Conserved Domains (1) summary
      cl21455
      Location:12 → 142
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_023526.4 → NP_076015.2  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_076015.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC154489, AK028539, AW490494, BC054390, BY332128
      Consensus CDS
      CCDS26836.1
      UniProtKB/Swiss-Prot
      Q8CEC5, Q9JKV3
      Related
      ENSMUSP00000121496.2, ENSMUST00000132374.9
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      4185693..4198560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247999.1 → XP_030103859.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X2

      Conserved Domains (1) summary
      cl38936
      Location:8 → 138
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_036158841.1 → XP_036014734.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X2

      Conserved Domains (1) summary
      cl38936
      Location:8 → 138
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_006518097.5 → XP_006518160.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006518160.1

      UniProtKB/Swiss-Prot
      Q8CEC5, Q9JKV3
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CEC5.1 GenPept UniProtKB/Swiss-Prot:Q8CEC5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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