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    Hddc2 HD domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 69692, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hddc2provided by MGI
    Official Full Name
    HD domain containing 2provided by MGI
    Primary source
    MGI:MGI:1916942
    See related
    Ensembl:ENSMUSG00000000295 AllianceGenome:MGI:1916942
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310057G13Rik
    Summary
    Predicted to enable 5'-deoxynucleotidase activity. Located in mitochondrion. Is expressed in heart. Orthologous to human HDDC2 (HD domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 2.8), ovary adult (RPKM 2.2) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hddc2 in Genome Data Viewer
    Location:
    10 A4; 10 17.34 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (31189296..31204200)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (31313330..31328204)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26212 Neighboring gene VISTA enhancer mm762 Neighboring gene spermine synthase pseudogene Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26213 Neighboring gene STARR-positive B cell enhancer ABC_E8329 Neighboring gene tumor protein D52-like 1 Neighboring gene SPT4B, DSIF elongation factor subunit Neighboring gene STARR-seq mESC enhancer starr_26215 Neighboring gene predicted gene, 51764

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of Hey2 transcription factor in the early embryonic ventricles is controlled through a distal enhancer by Tbx20 and Gata transcription factors. Ihara D, et al. Dev Biol, 2020 May 15. PMID 32035085
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129436, MGC129437

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-deoxynucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-deoxynucleotidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    5'-deoxynucleotidase HDDC2
    Names
    HD domain-containing protein 2
    NP_001403988.1
    NP_001403989.1
    NP_001403990.1
    NP_001403991.1
    NP_081444.1
    XP_030101112.1
    XP_036011879.1
    XP_036011880.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417059.1 → NP_001403988.1  5'-deoxynucleotidase HDDC2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153969

    2. NM_001417060.1 → NP_001403989.1  5'-deoxynucleotidase HDDC2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153969

    3. NM_001417061.1 → NP_001403990.1  5'-deoxynucleotidase HDDC2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153969

    4. NM_001417062.1 → NP_001403991.1  5'-deoxynucleotidase HDDC2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC153969

    5. NM_027168.2 → NP_081444.1  5'-deoxynucleotidase HDDC2 isoform 1

      See identical proteins and their annotated locations for NP_081444.1

      Status: PROVISIONAL

      Source sequence(s)
      BC104361
      Consensus CDS
      CCDS23767.1
      UniProtKB/Swiss-Prot
      Q3SXD3, Q9CV20
      Related
      ENSMUSP00000000304.7, ENSMUST00000000304.14
      Conserved Domains (1) summary
      pfam13023
      Location:19 → 175
      HD_3; HD domain

    RNA

    1. NR_184417.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153969

    2. NR_184418.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153969
      Related
      ENSMUST00000159194.3

    3. NR_184419.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153969

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      31189296..31204200
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155987.1 → XP_036011880.1  5'-deoxynucleotidase HDDC2 isoform X4

      Conserved Domains (1) summary
      cl21469
      Location:23 → 93
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    2. XM_030245252.1 → XP_030101112.1  5'-deoxynucleotidase HDDC2 isoform X2

      Conserved Domains (1) summary
      pfam13023
      Location:110 → 210
      HD_3; HD domain

    3. XM_036155986.1 → XP_036011879.1  5'-deoxynucleotidase HDDC2 isoform X3

      Conserved Domains (1) summary
      cl21469
      Location:110 → 177
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3SXD3.1 GenPept UniProtKB/Swiss-Prot:Q3SXD3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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