Il1rl2 interleukin 1 receptor-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il1rl2provided by MGI
Official Full Name: interleukin 1 receptor-like 2provided by MGI
Primary source: MGI:MGI:1913107
See related: Ensembl:ENSMUSG00000070942 AllianceGenome:MGI:1913107
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IL-1Rrp2
Summary: Predicted to enable cytokine receptor activity. Acts upstream of or within positive regulation of T cell differentiation; positive regulation of interleukin-6 production; and regulation of inflammatory response. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. Orthologous to human IL1RL2 (interleukin 1 receptor like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in mammary gland adult (RPKM 3.8), subcutaneous fat pad adult (RPKM 2.3) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 B; 1 18.96 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (40363697..40406722)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (40324589..40367555)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Floxed Il1rl2 Locus with mCherry Reporter Element Reveals Distinct Expression Patterns of the IL-36 Receptor in Barrier Tissues.
Title: Floxed Il1rl2 Locus with mCherry Reporter Element Reveals Distinct Expression Patterns of the IL-36 Receptor in Barrier Tissues.
Interleukin-38 promotes skin tumorigenesis in an IL-1Rrp2-dependent manner.
Title: Interleukin-38 promotes skin tumorigenesis in an IL-1Rrp2-dependent manner.
IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis.
Title: IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis.
IL-36R signaling integrates innate and adaptive immune-mediated protection against enteropathogenic bacteria.
Title: IL-36R signaling integrates innate and adaptive immune-mediated protection against enteropathogenic bacteria.
IL-36R likely contributes to acute kidney injury pathogenesis through NF-kB activity and IL-6 and TNF-a upregulation.
Title: Knockout of the interleukin-36 receptor protects against renal ischemia-reperfusion injury by reduction of proinflammatory cytokines.
these findings reveal a fundamental contribution for the IL-36/IL-36R axis in regulating the Treg-Th9 cell balance with broad implications for Th cell-mediated disorders, such as inflammatory bowel diseases and particularly ulcerative colitis
Title: IL-36γ signaling controls the induced regulatory T cell-Th9 cell balance via NFκB activation and STAT transcription factors.
IL-36R-deficient mice were protected from influenza virus-induced lung injury and mortality
Title: IL-36 receptor deletion attenuates lung injury and decreases mortality in murine influenza pneumonia.
Data show that Interleukin-36 receptor (IL-36R)-deficient fibroblast-like synoviocytes (FLS) had a limited capacity to support plasma cells (PC) survival compared to wild-type FLS.
Title: Interleukin-36 receptor mediates the crosstalk between plasma cells and synovial fibroblasts.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8)
Targeted (2) 1 citation

General gene information

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Markers

AI481289 (e-PCR)
- UniSTS:158790

NoName (e-PCR)
- UniSTS:234116

NoName (e-PCR)
- UniSTS:234117

AW551444 (e-PCR)
- UniSTS:178381

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD+ nucleosidase activity	IEA Inferred from Electronic Annotation more info
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IEA Inferred from Electronic Annotation more info
enables cytokine receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables interleukin-1, type I, activating receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-1-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-6 production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cellular_component	ND No biological Data available more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-1 receptor-like 2

Names: IL-36 receptor; IL1R-rp2; interleukin-1 receptor related protein 2

NP_001343407.1

EC 3.2.2.6

NP_573456.1

EC 3.2.2.6

XP_006495672.1

EC 3.2.2.6

XP_006495673.1

EC 3.2.2.6

XP_036021840.1

EC 3.2.2.6

XP_036021873.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356478.1 → NP_001343407.1 interleukin-1 receptor-like 2 precursor

Status: VALIDATED

Source sequence(s)

AC167168

Consensus CDS

CCDS14910.1

UniProtKB/Swiss-Prot

Q9ERS7

UniProtKB/TrEMBL

Q149G7

Related

ENSMUSP00000142248.2, ENSMUST00000194296.6

Conserved Domains (3) summary

pfam01582
Location:389 → 539

TIR; TIR domain

cd00096
Location:31 → 35

Ig; Ig strand A' [structural motif]

cl11960
Location:25 → 115

Ig; Immunoglobulin domain
NM_133193.4 → NP_573456.1 interleukin-1 receptor-like 2 precursor

See identical proteins and their annotated locations for NP_573456.1

Status: VALIDATED

Source sequence(s)

AC167168

Consensus CDS

CCDS14910.1

UniProtKB/Swiss-Prot

Q9ERS7

UniProtKB/TrEMBL

Q149G7

Related

ENSMUSP00000092630.4, ENSMUST00000095020.9

Conserved Domains (3) summary

pfam01582
Location:389 → 539

TIR; TIR domain

cd00096
Location:31 → 35

Ig; Ig strand A' [structural motif]

cl11960
Location:25 → 115

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

40363697..40406722

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165947.1 → XP_036021840.1 interleukin-1 receptor-like 2 isoform X1

UniProtKB/Swiss-Prot

Q9ERS7

UniProtKB/TrEMBL

Q149G7

Conserved Domains (3) summary

pfam01582
Location:389 → 539

TIR; TIR domain

cd00096
Location:31 → 35

Ig; Ig strand A' [structural motif]

cl11960
Location:25 → 115

Ig; Immunoglobulin domain
XM_006495609.4 → XP_006495672.1 interleukin-1 receptor-like 2 isoform X1

See identical proteins and their annotated locations for XP_006495672.1

UniProtKB/Swiss-Prot

Q9ERS7

UniProtKB/TrEMBL

Q149G7

Conserved Domains (3) summary

pfam01582
Location:389 → 539

TIR; TIR domain

cd00096
Location:31 → 35

Ig; Ig strand A' [structural motif]

cl11960
Location:25 → 115

Ig; Immunoglobulin domain
XM_006495610.5 → XP_006495673.1 interleukin-1 receptor-like 2 isoform X1

See identical proteins and their annotated locations for XP_006495673.1

UniProtKB/Swiss-Prot

Q9ERS7

UniProtKB/TrEMBL

Q149G7

Conserved Domains (3) summary

pfam01582
Location:389 → 539

TIR; TIR domain

cd00096
Location:31 → 35

Ig; Ig strand A' [structural motif]

cl11960
Location:25 → 115

Ig; Immunoglobulin domain
XM_036165980.1 → XP_036021873.1 interleukin-1 receptor-like 2 isoform X2

Conserved Domains (3) summary

pfam01582
Location:361 → 511

TIR; TIR domain

cd00096
Location:3 → 7

Ig; Ig strand A' [structural motif]

cl11960
Location:1 → 87

Ig; Immunoglobulin domain