Mmp16 matrix metallopeptidase 16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mmp16provided by MGI
Official Full Name: matrix metallopeptidase 16provided by MGI
Primary source: MGI:MGI:1276107
See related: Ensembl:ENSMUSG00000028226 AllianceGenome:MGI:1276107
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mt3mmp; MT3-MMP; MT-MMP 3
Summary: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit retarded growth of the skeleton, especially in the cranium and long bones. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression: Biased expression in CNS E18 (RPKM 3.8), limb E14.5 (RPKM 3.0) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A3; 4 7.08 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (17853072..18117479)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (17853072..18117479)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-155 contributed to the up-regulation of MMP-16, and MMP-16 further degraded aggrecan and collagen type II, leading to the dehydration and degeneration of intervertebral discs
Title: Role of miR-155 in the regulation of MMP-16 expression in intervertebral disc degeneration.
Neuronal knockdown of MT3-MMP resulted in the accumulation of NgR1 at the cell surface and reduced the accumulation of the NgR1 cleavage fragment in medium conditioned by cortical neurons
Title: Membrane-type matrix metalloproteinase-3 regulates neuronal responsiveness to myelin through Nogo-66 receptor 1 cleavage.
Study demonstrates that MT3-MMP, is expressed in mesenchymal tissues of the skeleton and in peri-skeletal soft connective tissue; and MT3-MMP-deficient mice display growth inhibition tied to a decreased viability of mesenchymal cells in skeletal tissues.
Title: Membrane-type MMPs enable extracellular matrix permissiveness and mesenchymal cell proliferation during embryogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (4) 1 citation

General gene information

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Markers

AB021228 (e-PCR)
- UniSTS:163337

D4Mit1 (e-PCR), detects polymorphism
- UniSTS:129872

Mmp16 (e-PCR), detects polymorphism
- UniSTS:495993

RH134462 (e-PCR)
- UniSTS:217742

45.MHAa92d9.seq (e-PCR)
- UniSTS:124565

MMP16_920 (e-PCR)
- UniSTS:277491

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metalloaminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within chondrocyte proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in collagen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within collagen catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within collagen catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within craniofacial suture morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endochondral ossification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ossification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein processing	IEA Inferred from Electronic Annotation more info
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in skeletal system development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: matrix metalloproteinase-16

Names: Membrane type 3-MMP; membrane-type matrix metalloproteinase 3

NP_001366447.1

EC 3.4.24.-

NP_001366448.1

EC 3.4.24.-

NP_062698.2

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001379518.1 → NP_001366447.1 matrix metalloproteinase-16 preproprotein

Status: VALIDATED

Description

Transcript Variant: This variant (3), as well as variants 1 and 4, encodes the functional protein.

Source sequence(s)

AL683877, AL805957

UniProtKB/Swiss-Prot

Q6PEQ6, Q9ERT6, Q9WTR0

Conserved Domains (5) summary

PHA03247
Location:292 → 338

PHA03247; large tegument protein UL36; Provisional

cd00094
Location:340 → 532

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam00413
Location:126 → 291

Peptidase_M10; Matrixin

pfam01471
Location:46 → 96

PG_binding_1; Putative peptidoglycan binding domain

pfam11857
Location:537 → 607

DUF3377; Domain of unknown function (DUF3377)
NM_001379519.1 → NP_001366448.1 matrix metalloproteinase-16 preproprotein

Status: VALIDATED

Description

Transcript Variant: This variant (4), as well as variants 1 and 3, encodes the functional protein.

Source sequence(s)

AL683877, AL805957

UniProtKB/Swiss-Prot

Q6PEQ6, Q9ERT6, Q9WTR0

Conserved Domains (5) summary

PHA03247
Location:292 → 338

PHA03247; large tegument protein UL36; Provisional

cd00094
Location:340 → 532

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam00413
Location:126 → 291

Peptidase_M10; Matrixin

pfam01471
Location:46 → 96

PG_binding_1; Putative peptidoglycan binding domain

pfam11857
Location:537 → 607

DUF3377; Domain of unknown function (DUF3377)
NM_019724.5 → NP_062698.2 matrix metalloproteinase-16 preproprotein

See identical proteins and their annotated locations for NP_062698.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the functional protein. Variants 1, 3, and 4 all encode the same protein.

Source sequence(s)

AL683877, AL805957

Consensus CDS

CCDS17989.1

UniProtKB/Swiss-Prot

Q6PEQ6, Q9ERT6, Q9WTR0

Related

ENSMUSP00000029881.4, ENSMUST00000029881.10

Conserved Domains (5) summary

PHA03247
Location:292 → 338

PHA03247; large tegument protein UL36; Provisional

cd00094
Location:340 → 532

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

pfam00413
Location:126 → 291

Peptidase_M10; Matrixin

pfam01471
Location:46 → 96

PG_binding_1; Putative peptidoglycan binding domain

pfam11857
Location:537 → 607

DUF3377; Domain of unknown function (DUF3377)

RNA

NR_135158.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains two alternate exons and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL683877, AL805957

Related

ENSMUST00000183662.8
NR_166735.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL683877, AL805957