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    Srsf4 serine and arginine-rich splicing factor 4 [ Mus musculus (house mouse) ]

    Gene ID: 57317, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Srsf4provided by MGI
    Official Full Name
    serine and arginine-rich splicing factor 4provided by MGI
    Primary source
    MGI:MGI:1890577
    See related
    Ensembl:ENSMUSG00000028911 AllianceGenome:MGI:1890577
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SRp75; Sfrs4; MNCb-2616; 5730499P16Rik
    Summary
    The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Sep 2010]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 39.5), CNS E14 (RPKM 24.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Srsf4 in Genome Data Viewer
    Location:
    4 D2.3; 4 64.53 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (131600841..131629036)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (131873530..131901725)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type U Neighboring gene predicted gene, 52680 Neighboring gene STARR-positive B cell enhancer ABC_E10262 Neighboring gene mitochondrial trans-2-enoyl-CoA reductase Neighboring gene predicted gene 12992 Neighboring gene phosphatidylinositol 3-kinase, catalytic, beta polypeptide pseudogene Neighboring gene transmembrane protein 200B Neighboring gene erythrocyte membrane protein band 4.1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A. Yomoda J, et al. Genes Cells, 2008 Mar. PMID 18298798
    2. The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes. Änkö ML, et al. Genome Biol, 2012. PMID 22436691, Free PMC Article
    3. Androgen receptor binding to an androgen-responsive element in the promoter of the Srsf4 gene inhibits its expression in mouse Sertoli cells. Guo H, et al. Mol Reprod Dev, 2015 Dec. PMID 26308373
    4. Global analysis reveals SRp20- and SRp75-specific mRNPs in cycling and neural cells. Ankö ML, et al. Nat Struct Mol Biol, 2010 Aug. PMID 20639886
    5. The SRSF4-GAS5-Glucocorticoid Receptor Axis Regulates Ventricular Hypertrophy. Larrasa-Alonso J, et al. Circ Res, 2021 Sep 3. PMID 34333993, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The SRSF4-GAS5-Glucocorticoid Receptor Axis Regulates Ventricular Hypertrophy.
      Title: The SRSF4-GAS5-Glucocorticoid Receptor Axis Regulates Ventricular Hypertrophy.
    2. these results demonstrate that Srsf4 is a direct downstream target of the androgen receptor in mouse Sertoli cells.
      Title: Androgen receptor binding to an androgen-responsive element in the promoter of the Srsf4 gene inhibits its expression in mouse Sertoli cells.
    3. SRSF3 and SRSF4 proteins bind to the 3' ends of the majority of intronless histone transcripts, implicating SRSF3 and SRSF4 in histone mRNA metabolism.
      Title: The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes.
    4. mRNA targets of SRp20 and SRp75 were identified in cycling and neurally induced P19 cells.
      Title: Global analysis reveals SRp20- and SRp75-specific mRNPs in cycling and neural cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/arginine-rich splicing factor 4
    Names
    splicing factor, arginine/serine-rich 4 (SRp75)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001369308.1 → NP_001356237.1  serine/arginine-rich splicing factor 4 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AL607088
      Conserved Domains (3) summary
      cd12600
      Location:109 → 180
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      TIGR01642
      Location:250 → 361
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      cl17169
      Location:42 → 77
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001369309.1 → NP_001356238.1  serine/arginine-rich splicing factor 4 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AL607088
      Conserved Domains (3) summary
      cd12600
      Location:109 → 180
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      TIGR01642
      Location:250 → 361
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      cl17169
      Location:42 → 77
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001369310.1 → NP_001356239.1  serine/arginine-rich splicing factor 4 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AL607088
      Conserved Domains (3) summary
      cd12600
      Location:109 → 180
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      TIGR01642
      Location:250 → 361
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      cl17169
      Location:42 → 77
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. NM_001369311.1 → NP_001356240.1  serine/arginine-rich splicing factor 4 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
      Source sequence(s)
      AL607088
      Conserved Domains (3) summary
      cd12600
      Location:109 → 180
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      TIGR01642
      Location:250 → 361
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      cl17169
      Location:42 → 77
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. NM_001369312.1 → NP_001356241.1  serine/arginine-rich splicing factor 4 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AL607088
      Conserved Domains (2) summary
      cd12600
      Location:29 → 100
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      TIGR01642
      Location:170 → 281
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

    6. NM_020587.2 → NP_065612.2  serine/arginine-rich splicing factor 4 isoform b

      See identical proteins and their annotated locations for NP_065612.2

      Status: REVIEWED

      Source sequence(s)
      AK075769, AK077648, AV016063, BY107258
      Consensus CDS
      CCDS51315.1
      UniProtKB/TrEMBL
      Q542V3
      Related
      ENSMUSP00000061474.4, ENSMUST00000053819.6
      Conserved Domains (2) summary
      cd12337
      Location:3 → 72
      RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cd12600
      Location:104 → 175
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      131600841..131629036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320335.2 → XP_017175824.1  serine/arginine-rich splicing factor 4 isoform X2

      Conserved Domains (2) summary
      TIGR01642
      Location:122 → 234
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      cl17169
      Location:1 → 52
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_036164281.1 → XP_036020174.1  serine/arginine-rich splicing factor 4 isoform X2

      Conserved Domains (2) summary
      TIGR01642
      Location:122 → 234
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      cl17169
      Location:1 → 52
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_017320333.3 → XP_017175822.1  serine/arginine-rich splicing factor 4 isoform X1

      Conserved Domains (3) summary
      cd12600
      Location:109 → 180
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      TIGR01642
      Location:250 → 361
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      cl17169
      Location:42 → 77
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. XM_030253687.2 → XP_030109547.1  serine/arginine-rich splicing factor 4 isoform X2

      Conserved Domains (2) summary
      TIGR01642
      Location:122 → 234
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      cl17169
      Location:1 → 52
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. XM_036164282.1 → XP_036020175.1  serine/arginine-rich splicing factor 4 isoform X2

      Conserved Domains (2) summary
      TIGR01642
      Location:122 → 234
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      cl17169
      Location:1 → 52
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VE97.1 GenPept UniProtKB/Swiss-Prot:Q8VE97

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