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    Nemp2 nuclear envelope integral membrane protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 227094, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nemp2provided by MGI
    Official Full Name
    nuclear envelope integral membrane protein 2provided by MGI
    Primary source
    MGI:MGI:2444113
    See related
    Ensembl:ENSMUSG00000043015 AllianceGenome:MGI:2444113
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem194b; 9830163O08; 5330401P04Rik
    Summary
    Predicted to be located in nuclear inner membrane. Predicted to be active in nuclear envelope. Orthologous to human NEMP2 (nuclear envelope integral membrane protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 6.7), thymus adult (RPKM 6.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nemp2 in Genome Data Viewer
    Location:
    1 C1.1; 1 26.99 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (52669850..52691078)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (52568535..52651919)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 53065 Neighboring gene STARR-seq mESC enhancer starr_00902 Neighboring gene predicted gene 28178 Neighboring gene STARR-seq mESC enhancer starr_00903 Neighboring gene predicted gene 5527 Neighboring gene STARR-positive B cell enhancer ABC_E5753 Neighboring gene major facilitator superfamily domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_00904 Neighboring gene STARR-positive B cell enhancer ABC_E3274 Neighboring gene STARR-positive B cell enhancer ABC_E1543 Neighboring gene inositol polyphosphate-1-phosphatase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    3. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear envelope integral membrane protein 2
    Names
    transmembrane protein 194B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142647.1 → NP_001136119.1  nuclear envelope integral membrane protein 2 precursor

      See identical proteins and their annotated locations for NP_001136119.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AI153571, BB848894, BC094370, CD553439
      Consensus CDS
      CCDS48257.1
      UniProtKB/Swiss-Prot
      Q8C844, Q8CB65
      Related
      ENSMUSP00000129351.2, ENSMUST00000165859.8
      Conserved Domains (1) summary
      pfam10225
      Location:142 → 389
      DUF2215; Uncharacterized conserved protein (DUF2215)

    RNA

    1. NR_024590.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the central coding region, compared to variant 1, that results in a frameshift. This variant is represented as non-coding because the frameshift renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK036693, BB848894, BC094370

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      52669850..52691078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003954987.1 RNA Sequence

      Related
      ENSMUST00000188507.7

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172654.2: Suppressed sequence

      Description
      NM_172654.2: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from chicken: LOC423977 (GeneID:423977).
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CB65.3 GenPept UniProtKB/Swiss-Prot:Q8CB65

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