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    Strap serine/threonine kinase receptor associated protein [ Mus musculus (house mouse) ]

    Gene ID: 20901, updated on 9-Dec-2024

    Summary

    Official Symbol
    Strapprovided by MGI
    Official Full Name
    serine/threonine kinase receptor associated proteinprovided by MGI
    Primary source
    MGI:MGI:1329037
    See related
    Ensembl:ENSMUSG00000030224 AllianceGenome:MGI:1329037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Unrip
    Summary
    Enables U2 snRNP binding activity; mRNA binding activity; and signaling receptor binding activity. Involved in alternative mRNA splicing, via spliceosome; neuron differentiation; and protein-RNA complex assembly. Acts upstream of or within negative regulation of transcription by RNA polymerase II and negative regulation of transforming growth factor beta receptor signaling pathway. Is active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; metanephros; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in adenocarcinoma; colorectal carcinoma; large cell carcinoma; lung carcinoma; and squamous cell neoplasm. Orthologous to human STRAP (serine/threonine kinase receptor associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 42.9), testis adult (RPKM 34.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Strap in Genome Data Viewer
    Location:
    6 G1; 6 67.27 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (137712080..137728928)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (137735082..137751930)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene epidermal growth factor receptor pathway substrate 8 Neighboring gene STARR-seq mESC enhancer starr_17627 Neighboring gene STARR-seq mESC enhancer starr_17628 Neighboring gene STARR-seq mESC enhancer starr_17630 Neighboring gene STARR-seq mESC enhancer starr_17631 Neighboring gene predicted gene, 38915 Neighboring gene STARR-positive B cell enhancer ABC_E4877 Neighboring gene STARR-positive B cell enhancer ABC_E4878 Neighboring gene deoxyribose-phosphate aldolase Neighboring gene STARR-seq mESC enhancer starr_17633 Neighboring gene predicted gene, 38552

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables U2 snRNP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SMN complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SMN complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SMN complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of SMN-Sm protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SMN-Sm protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine-threonine kinase receptor-associated protein
    Names
    UNR-interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011499.3NP_035629.2  serine-threonine kinase receptor-associated protein

      See identical proteins and their annotated locations for NP_035629.2

      Status: VALIDATED

      Source sequence(s)
      AK145971, AK147179
      Consensus CDS
      CCDS51945.1
      UniProtKB/Swiss-Prot
      Q8BP89, Q8C6F6, Q9Z1Z2
      UniProtKB/TrEMBL
      B2RUC7
      Related
      ENSMUSP00000068267.7, ENSMUST00000064910.7
      Conserved Domains (3) summary
      COG2319
      Location:11292
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:9293
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:104141
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      137712080..137728928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)