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    Thoc1 THO complex 1 [ Mus musculus (house mouse) ]

    Gene ID: 225160, updated on 9-Dec-2024

    Summary

    Official Symbol
    Thoc1provided by MGI
    Official Full Name
    THO complex 1provided by MGI
    Primary source
    MGI:MGI:1919668
    See related
    Ensembl:ENSMUSG00000024287 AllianceGenome:MGI:1919668
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    tho1; NMP-84; 3110002N20Rik
    Summary
    Predicted to enable DNA binding activity and RNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to act upstream of or within apoptotic process and regulation of apoptotic process. Predicted to be located in cytoplasm and nuclear speck. Predicted to be part of THO complex part of transcription export complex. Predicted to colocalize with chromosome, telomeric region. Is expressed in early conceptus and embryo. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human THOC1 (THO complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 14.3), CNS E18 (RPKM 13.3) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Thoc1 in Genome Data Viewer
    Location:
    18 A1; 18 4.91 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (9958176..9995486)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (9958180..9995484)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43785 Neighboring gene cell division cycle associated 7 pseudogene Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43786 Neighboring gene ubiquitin specific peptidase 14 Neighboring gene STARR-seq mESC enhancer starr_43787 Neighboring gene STARR-seq mESC enhancer starr_43788 Neighboring gene STARR-seq mESC enhancer starr_43789 Neighboring gene Rho-associated coiled-coil containing protein kinase 1 Neighboring gene LSM6 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene predicted gene, 26244

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC28284

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of THO complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of THO complex part of transcription export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of THO complex part of transcription export complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of THO complex part of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    THO complex subunit 1
    Names
    nuclear matrix protein p84

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417745.1NP_001404674.1  THO complex subunit 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114677, AC163451
    2. NM_001417749.1NP_001404678.1  THO complex subunit 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC114677, AC163451
    3. NM_001417750.1NP_001404679.1  THO complex subunit 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC114677, AC163451
    4. NM_001417753.1NP_001404682.1  THO complex subunit 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC114677, AC163451
    5. NM_001417754.1NP_001404683.1  THO complex subunit 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC114677, AC163451
    6. NM_001417760.1NP_001404689.1  THO complex subunit 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC114677, AC163451
    7. NM_153552.4NP_705780.1  THO complex subunit 1 isoform 1

      See identical proteins and their annotated locations for NP_705780.1

      Status: VALIDATED

      Source sequence(s)
      AC114677, AC163451
      Consensus CDS
      CCDS37733.1
      UniProtKB/Swiss-Prot
      Q8BWD5, Q8BXY3, Q8R3N6
      Related
      ENSMUSP00000025137.8, ENSMUST00000025137.9
      Conserved Domains (2) summary
      cd08318
      Location:565650
      Death_NMPP84; Death domain of Nuclear Matrix Protein P84
      pfam11957
      Location:74539
      efThoc1; THO complex subunit 1 transcription elongation factor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      9958176..9995486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)