Efcab2 EF-hand calcium binding domain 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Efcab2provided by MGI
Official Full Name: EF-hand calcium binding domain 2provided by MGI
Primary source: MGI:MGI:1915476
See related: Ensembl:ENSMUSG00000026495 AllianceGenome:MGI:1915476
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700073K01Rik; D830011E08Rik
Summary: Enables calcium ion binding activity. Located in sperm principal piece. Is expressed in several structures, including endocrine gland; forelimb bud; genitourinary system; lung; and nervous system. Orthologous to human EFCAB2 (EF-hand calcium binding domain 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 5.9), heart adult (RPKM 4.2) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H4; 1 83.16 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (178233583..178312078)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (178406018..178484513)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EFCAB2 is a novel calcium-binding protein in mouse testis and sperm.
Title: EFCAB2 is a novel calcium-binding protein in mouse testis and sperm.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in sperm principal piece	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm principal piece	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dynein regulatory complex protein 8

Names: EF-hand calcium-binding domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026626.3 → NP_080902.1 dynein regulatory complex protein 8

See identical proteins and their annotated locations for NP_080902.1

Status: VALIDATED

Source sequence(s)

AC157809

Consensus CDS

CCDS15557.1

UniProtKB/Swiss-Prot

Q9CQ46, Q9CS07

Related

ENSMUSP00000027775.8, ENSMUST00000027775.9

Conserved Domains (2) summary

PTZ00184
Location:10 → 160

PTZ00184; calmodulin; Provisional

cl08302
Location:99 → 159

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...