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    Sp5 trans-acting transcription factor 5 [ Mus musculus (house mouse) ]

    Gene ID: 64406, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sp5provided by MGI
    Official Full Name
    trans-acting transcription factor 5provided by MGI
    Primary source
    MGI:MGI:1927715
    See related
    Ensembl:ENSMUSG00000075304 AllianceGenome:MGI:1927715
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within bone morphogenesis; cellular response to organic cyclic compound; and post-anal tail morphogenesis. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; embryo ectoderm; and embryo mesenchyme. Orthologous to human SP5 (Sp5 transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in duodenum adult (RPKM 49.5), small intestine adult (RPKM 18.4) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sp5 in Genome Data Viewer
    Location:
    2 C2; 2 41.49 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (70305267..70308070)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (70474923..70477726)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4463 Neighboring gene myosin IIIB Neighboring gene STARR-seq mESC enhancer starr_04751 Neighboring gene STARR-seq mESC enhancer starr_04752 Neighboring gene STARR-seq mESC enhancer starr_04756 Neighboring gene STARR-seq mESC enhancer starr_04757 Neighboring gene STARR-seq mESC enhancer starr_04758 Neighboring gene STARR-seq mESC enhancer starr_04760 Neighboring gene STARR-seq mESC enhancer starr_04762 Neighboring gene ribosomal protein L9, pseudogene 7 Neighboring gene glutamate decarboxylase 1, opposite strand Neighboring gene glutamate rich 2 Neighboring gene STARR-seq mESC enhancer starr_04764 Neighboring gene glutamate decarboxylase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    General gene information

    Markers

    Clone Names

    • MGC144801, MGC144802

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022435.2NP_071880.1  transcription factor Sp5

      See identical proteins and their annotated locations for NP_071880.1

      Status: PROVISIONAL

      Source sequence(s)
      AK036234
      Consensus CDS
      CCDS16106.1
      UniProtKB/Swiss-Prot
      Q149T2, Q9JHX2
      Related
      ENSMUSP00000097620.3, ENSMUST00000100043.3
      Conserved Domains (5) summary
      COG5048
      Location:311384
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301320
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:342365
      zf-H2C2_2; Zinc-finger double domain
      cd22541
      Location:106297
      SP5_N; N-terminal domain of transcription factor Specificity Protein (SP) 5
      cl41773
      Location:3147
      SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      70305267..70308070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)