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    Snapin SNAP-associated protein [ Mus musculus (house mouse) ]

    Gene ID: 20615, updated on 9-Dec-2024

    Summary

    Official Symbol
    Snapinprovided by MGI
    Official Full Name
    SNAP-associated proteinprovided by MGI
    Primary source
    MGI:MGI:1333745
    See related
    Ensembl:ENSMUSG00000001018 AllianceGenome:MGI:1333745
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    25kDa; Snapap; Bloc1s7; Snap25bp
    Summary
    Predicted to enable SNARE binding activity. Involved in anterograde synaptic vesicle transport; negative regulation of neuron projection development; and regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including lysosomal lumen acidification; terminal button organization; and vesicle organization. Located in acrosomal vesicle; cytosol; and manchette. Part of BLOC-1 complex. Is active in microvesicle. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human SNAPIN (SNAP associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 30.5), heart adult (RPKM 20.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Snapin in Genome Data Viewer
    Location:
    3 F1; 3 39.24 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (90395333..90398320, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90488026..90491013, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene natriuretic peptide receptor 1 Neighboring gene STARR-positive B cell enhancer ABC_E6072 Neighboring gene STARR-positive B cell enhancer ABC_E56 Neighboring gene nuclear encoded tRNA methionine 11 (anticodon CAT) Neighboring gene interleukin enhancer binding factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E2084 Neighboring gene chromatin target of PRMT1 Neighboring gene STARR-positive B cell enhancer ABC_E2085 Neighboring gene STARR-seq mESC enhancer starr_08290 Neighboring gene S100 calcium binding protein A1 Neighboring gene S100 calcium binding protein A13

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (5)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SNARE binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in anterograde axonal transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in anterograde synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within autophagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium-ion regulated exocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endosome to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within establishment of vesicle localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within late endosome to lysosome transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lysosomal lumen acidification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lysosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lysosome localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lysosome localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lysosome localization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in lysosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within lysosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in melanosome organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neuron cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in organelle transport along microtubule NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within protein maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein-containing complex localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of endosome size NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of lysosome size NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within retrograde axonal transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within synaptic vesicle fusion to presynaptic active zone membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within synaptic vesicle maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synaptic vesicle transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic vesicle transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within terminal button organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of BLOC-1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of BLOC-1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of BLOC-1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of BORC complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic side of lysosomal membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in manchette IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in microvesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    SNARE-associated protein Snapin
    Names
    BLOC-1 subunit 7
    biogenesis of lysosome-related organelles complex 1 subunit 7
    synaptosomal-associated protein 25 binding protein
    synaptosomal-associated protein, 25 kDa, binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133854.3NP_598615.1  SNARE-associated protein Snapin

      See identical proteins and their annotated locations for NP_598615.1

      Status: VALIDATED

      Source sequence(s)
      AC160552, AK048007, AK050151
      Consensus CDS
      CCDS17531.1
      UniProtKB/Swiss-Prot
      Q3U8V4, Q922V7, Q9Z266
      UniProtKB/TrEMBL
      Q3UY32
      Related
      ENSMUSP00000122090.2, ENSMUST00000149884.2
      Conserved Domains (1) summary
      pfam14712
      Location:24110
      Snapin_Pallidin; Snapin/Pallidin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      90395333..90398320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)