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    Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 [ Mus musculus (house mouse) ]

    Gene ID: 68197, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ndufc2provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit C2provided by MGI
    Primary source
    MGI:MGI:1344370
    See related
    Ensembl:ENSMUSG00000030647 AllianceGenome:MGI:1344370
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G1; 1810004I06Rik; 2010300P09Rik
    Summary
    Predicted to be involved in several processes, including mitochondrial respiratory chain complex I assembly; negative regulation of non-canonical NF-kappaB signal transduction; and positive regulation of ATP biosynthetic process. Located in mitochondrial inner membrane. Is expressed in several structures, including gut; male reproductive gland or organ; and nervous system. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency. Orthologous to several human genes including NDUFC2 (NADH:ubiquinone oxidoreductase subunit C2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 105.2), adrenal adult (RPKM 98.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ndufc2 in Genome Data Viewer
    Location:
    7 E1; 7 53.49 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (97049210..97057007)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (97400003..97407800)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr7:104480601-104480902 Neighboring gene potassium channel tetramerisation domain containing 21 Neighboring gene STARR-seq mESC enhancer starr_19591 Neighboring gene STARR-positive B cell enhancer ABC_E9293 Neighboring gene ALG8 alpha-1,3-glucosyltransferase Neighboring gene STARR-seq mESC enhancer starr_19594 Neighboring gene thyroid hormone responsive Neighboring gene predicted gene, 32945

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in aerobic respiration NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in mitochondrial electron transport, NADH to ubiquinone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of reactive oxygen species biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ATP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proton motive force-driven mitochondrial ATP synthesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
     
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 subunit C2
    Names
    14.5b subunit of the NADH-ubiquinone dehydrogenase complex
    CI-B14.5b
    NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2
    NADH-ubiquinone oxidoreductase subunit B14.5b
    complex I-B14.5b
    NP_077182.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024220.2NP_077182.1  NADH dehydrogenase [ubiquinone] 1 subunit C2

      See identical proteins and their annotated locations for NP_077182.1

      Status: VALIDATED

      Source sequence(s)
      AI413456, CK128102
      Consensus CDS
      CCDS21457.1
      UniProtKB/Swiss-Prot
      Q3TLB2, Q9CQ54
      UniProtKB/TrEMBL
      Q9D846
      Related
      ENSMUSP00000032882.9, ENSMUST00000032882.9
      Conserved Domains (1) summary
      pfam06374
      Location:11120
      NDUF_C2; NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      97049210..97057007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)