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    Gorasp2 golgi reassembly stacking protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 70231, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gorasp2provided by MGI
    Official Full Name
    golgi reassembly stacking protein 2provided by MGI
    Primary source
    MGI:MGI:2135962
    See related
    Ensembl:ENSMUSG00000014959 AllianceGenome:MGI:2135962
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p59; GRS2; GOLPH2; GRASP55; 0610011A07Rik; 2410043M02Rik; 5730520M13Rik; 9430094F20Rik
    Summary
    Predicted to be involved in several processes, including Golgi organization; establishment of protein localization to plasma membrane; and response to endoplasmic reticulum stress. Predicted to be located in Golgi medial cisterna; Golgi membrane; and endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including brain and retina nuclear layer. Orthologous to human GORASP2 (golgi reassembly stacking protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 74.9), adrenal adult (RPKM 71.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gorasp2 in Genome Data Viewer
    Location:
    2 C2; 2 41.82 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (70491520..70522069)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (70661509..70691725)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 16510 Neighboring gene predicted gene, 46745 Neighboring gene STARR-positive B cell enhancer ABC_E7823 Neighboring gene STARR-seq mESC enhancer starr_04765 Neighboring gene predicted gene, 38528 Neighboring gene tousled-like kinase 1 Neighboring gene STARR-seq mESC enhancer starr_04766 Neighboring gene STARR-seq mESC enhancer starr_04767 Neighboring gene STARR-positive B cell enhancer ABC_E11136 Neighboring gene STARR-positive B cell enhancer ABC_E10112 Neighboring gene predicted gene, 39842

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in organelle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in organelle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in organelle organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in organelle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in Golgi medial cisterna ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    Golgi reassembly-stacking protein 2
    Names
    golgi reassembly-stacking protein of 55 kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027352.4NP_081628.3  Golgi reassembly-stacking protein 2

      See identical proteins and their annotated locations for NP_081628.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the protein-coding transcript.
      Source sequence(s)
      AK169382, BU707592
      Consensus CDS
      CCDS16109.1
      UniProtKB/Swiss-Prot
      Q3U9D2, Q8CCD0, Q91W68, Q99JX3
      UniProtKB/TrEMBL
      Q3TX06
      Related
      ENSMUSP00000028509.5, ENSMUST00000028509.11
      Conserved Domains (2) summary
      pfam04495
      Location:69205
      GRASP55_65; GRASP55/65 PDZ-like domain
      cl00117
      Location:14100
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

    RNA

    1. NR_027343.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon compared to variant 1, that disrupts the reading frame. This variant is not thought to be protein-coding.
      Source sequence(s)
      AK168928, AK169382, BU707592
      Related
      ENSMUST00000112201.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      70491520..70522069
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162559.1XP_036018452.1  Golgi reassembly-stacking protein 2 isoform X1

      UniProtKB/TrEMBL
      Q3TX06
      Conserved Domains (2) summary
      pfam04495
      Location:69205
      GRASP55_65; GRASP55/65 PDZ-like domain
      cl00117
      Location:14100
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...