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    Zfp998 zinc finger protein 998 [ Mus musculus (house mouse) ]

    Gene ID: 76803, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp998provided by MGI
    Official Full Name
    zinc finger protein 998provided by MGI
    Primary source
    MGI:MGI:1924053
    See related
    Ensembl:ENSMUSG00000074832 AllianceGenome:MGI:1924053
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Snerv1; Ayu21-35; 2410141K09Rik; 4930482J15Rik; Gt(pU21)35Imeg
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Orthologous to several human genes including ZNF117 (zinc finger protein 117); ZNF490 (zinc finger protein 490); and ZNF708 (zinc finger protein 708). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Zfp998 in Genome Data Viewer
    Location:
    13 B3; 13 34.52 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (66566173..66589190, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (66418114..66441118, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26715 Neighboring gene predicted gene, 33043 Neighboring gene STARR-seq mESC enhancer starr_34869 Neighboring gene upstream binding transcription factor, RNA polymerase I pseudogene Neighboring gene STARR-seq mESC enhancer starr_34870 Neighboring gene STARR-seq mESC enhancer starr_34871 Neighboring gene STARR-seq mESC enhancer starr_34873 Neighboring gene vomeronasal 2, receptor, pseudogene 105 Neighboring gene predicted gene, 46428

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gv1, a Zinc Finger Gene Controlling Endogenous MLV Expression. Young GR, et al. Mol Biol Evol, 2021 May 19. PMID 33560369, Free PMC Article
    2. The Lupus Susceptibility Locus Sgp3 Encodes the Suppressor of Endogenous Retrovirus Expression SNERV. Treger RS, et al. Immunity, 2019 Feb 19. PMID 30709743, Free PMC Article
    3. Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes. Ostapcuk V, et al. Nature, 2018 May. PMID 29795351
    4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein-like
    Names
    Gt(Ayu21)35Imeg

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290196.2 → NP_001277125.1  zinc finger protein-like isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (a).
      Source sequence(s)
      AC164297, AK010804
      Consensus CDS
      CCDS84031.1
      UniProtKB/TrEMBL
      K7N769
      Related
      ENSMUSP00000134352.3, ENSMUST00000172579.4
      Conserved Domains (5) summary
      smart00349
      Location:4 → 46
      KRAB; krueppel associated box
      COG5048
      Location:72 → 452
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:77 → 97
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:117 → 142
      zf-H2C2_2; Zinc-finger double domain

    2. NM_183119.3 → NP_898942.1  zinc finger protein-like isoform b

      See identical proteins and their annotated locations for NP_898942.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains alternate 3' exon structure, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC164297, AK010804
      Consensus CDS
      CCDS70474.1
      UniProtKB/TrEMBL
      Q8C1L2
      Related
      ENSMUSP00000134048.2, ENSMUST00000173583.8
      Conserved Domains (2) summary
      smart00349
      Location:4 → 46
      KRAB; krueppel associated box
      pfam01352
      Location:4 → 43
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      66566173..66589190 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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