Creld2 cysteine-rich with EGF-like domains 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Creld2provided by MGI
Official Full Name: cysteine-rich with EGF-like domains 2provided by MGI
Primary source: MGI:MGI:1923987
See related: Ensembl:ENSMUSG00000023272 AllianceGenome:MGI:1923987
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5730592L21Rik
Summary: Predicted to enable calcium ion binding activity and protein disulfide isomerase activity. Predicted to be an extracellular matrix structural constituent. Located in Golgi apparatus; endoplasmic reticulum; and extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; long bone; and respiratory system. Orthologous to human CRELD2 (cysteine rich with EGF like domains 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 146.2), ovary adult (RPKM 63.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E3; 15 44.31 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (88703849..88710884)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (88819646..88826681)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cysteine-rich with EGF-like domains 2 (CRELD2) is an endoplasmic reticulum stress-inducible angiogenic growth factor promoting ischemic heart repair.
Title: Cysteine-rich with EGF-like domains 2 (CRELD2) is an endoplasmic reticulum stress-inducible angiogenic growth factor promoting ischemic heart repair.
Creld2 function during unfolded protein response is essential for liver metabolism homeostasis.
Title: Creld2 function during unfolded protein response is essential for liver metabolism homeostasis.
results strongly suggest that Creld2 may be directly regulated by BMP9 and ER stress response may play an important role in regulating osteogenic differentiation
Title: Endoplasmic reticulum (ER) stress inducible factor cysteine-rich with EGF-like domains 2 (Creld2) is an important mediator of BMP9-regulated osteogenic differentiation of mesenchymal stem cells.
These results show that the mouse CRELD2 and ALG12 genes are arranged as a unique bidirectional gene pair.
Title: Role of an ER stress response element in regulating the bidirectional promoter of the mouse CRELD2 - ALG12 gene pair.
CRELD2 could be a novel mediator in regulating the onset and progression of various ER stress-associated diseases.
Title: CRELD2 is a novel endoplasmic reticulum stress-inducible gene.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables molecular_function	ND No biological Data available more info
enables protein disulfide isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein disulfide isomerase Creld2

Names: cysteine-rich with EGF-like domain protein 2

NP_083996.1

EC 5.3.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029720.2 → NP_083996.1 protein disulfide isomerase Creld2 precursor

See identical proteins and their annotated locations for NP_083996.1

Status: PROVISIONAL

Source sequence(s)

AK017880

Consensus CDS

CCDS27733.1

UniProtKB/Swiss-Prot

Q9CYA0

Related

ENSMUSP00000024042.4, ENSMUST00000024042.5

Conserved Domains (3) summary

smart00261
Location:253 → 288

FU; Furin-like repeats

cd00064
Location:196 → 246

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

cl00057
Location:286 → 326

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...