Mir32 microRNA 32 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mir32provided by MGI
Official Full Name: microRNA 32provided by MGI
Primary source: MGI:MGI:3619331
See related: Ensembl:ENSMUSG00000065544 miRBase:MI0000691; AllianceGenome:MGI:3619331
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mirn32; mir-32; mmu-mir-32
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 4 B3; 4 31.66 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (56895229..56895298, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (56895229..56895298, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A CEBPB/miR-32-5p/GATA6 axis promotes vascular calcification in type 2 diabetes.
Title: A CEBPB/miR-32-5p/GATA6 axis promotes vascular calcification in type 2 diabetes.
miR-32-5p induces hepatic steatosis and hyperlipidemia by triggering de novo lipogenesis.
Title: miR-32-5p induces hepatic steatosis and hyperlipidemia by triggering de novo lipogenesis.
Extracellular vesicle miR-32 derived from macrophage promotes arterial calcification in mice with type 2 diabetes via inhibiting VSMC autophagy.
Title: Extracellular vesicle miR-32 derived from macrophage promotes arterial calcification in mice with type 2 diabetes via inhibiting VSMC autophagy.
MicroRNA-32-5p knockout eliminates lipopolysaccharide-induced depressive-like behavior in mice through inhibition of astrocyte overactivity.
Title: MicroRNA-32-5p knockout eliminates lipopolysaccharide-induced depressive-like behavior in mice through inhibition of astrocyte overactivity.
miR32-5p promoted vascular smooth muscle cell calcification by upregulating TNFalpha in the microenvironment.
Title: miR32-5p promoted vascular smooth muscle cell calcification by upregulating TNFα in the microenvironment.
miR-32 promotes brown fat thermogenesis. miR-32 directly inhibits Tob1 to activate p38/MAPK signaling to induce FGF21 in BAT.
Title: miRNA-32 Drives Brown Fat Thermogenesis and Trans-activates Subcutaneous White Fat Browning in Mice.
that miR-32 increases proliferation and promotes metaplastic transformation in mouse prostate epithelium
Title: In Vivo Expression of miR-32 Induces Proliferation in Prostate Epithelium.
Results confirmed miR-32 as a critical modulator of vascular calcification through its targeting of the PTEN/Akt/RUNX2 axis in mice. Moreover, results of analyses of plasma from CAD patients revealed that plasma miR-32 levels were positively correlated with coronary artery calcification (CAC) and might serve as a diagnostic marker in coronary artery disease patients with CAC.
Title: MicroRNA-32 promotes calcification in vascular smooth muscle cells: Implications as a novel marker for coronary artery calcification.
miR-32/MCL-1 pathway members were identified as key early genetic events driving melanoma progression.
Title: Integrated Genomics Identifies miR-32/MCL-1 Pathway as a Critical Driver of Melanomagenesis: Implications for miR-Replacement and Combination Therapy.
our data suggest that miR-32 and its downstream target SLC45A3 play important roles in myelin maintenance
Title: miR-32 and its target SLC45A3 regulate the lipid metabolism of oligodendrocytes and myelin.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.