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    Rfc3 replication factor C (activator 1) 3 [ Mus musculus (house mouse) ]

    Gene ID: 69263, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rfc3provided by MGI
    Official Full Name
    replication factor C (activator 1) 3provided by MGI
    Primary source
    MGI:MGI:1916513
    See related
    Ensembl:ENSMUSG00000033970 AllianceGenome:MGI:1916513
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    38kDa; Recc3; 2810416I22Rik
    Summary
    Predicted to enable ATP-dependent activity, acting on DNA. Predicted to contribute to DNA binding activity; DNA clamp loader activity; and single-stranded DNA helicase activity. Predicted to be involved in DNA repair; DNA-templated DNA replication; and positive regulation of DNA-directed DNA polymerase activity. Predicted to be part of Ctf18 RFC-like complex and DNA replication factor C complex. Predicted to be active in nucleus. Is expressed in central nervous system; liver; retina nuclear layer; skeletal muscle; and submandibular gland primordium. Orthologous to human RFC3 (replication factor C subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 28.7), liver E14 (RPKM 20.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rfc3 in Genome Data Viewer
    Location:
    5 G3; 5 90.18 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (151566282..151574673, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (151642817..151651208, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor, pseudogene 27 Neighboring gene vomeronasal 2, receptor, pseudogene 28 Neighboring gene STARR-positive B cell enhancer ABC_E1699 Neighboring gene predicted gene, 24242 Neighboring gene STARR-seq mESC enhancer starr_14978 Neighboring gene STARR-seq mESC enhancer starr_14979 Neighboring gene STARR-seq mESC enhancer starr_14980 Neighboring gene STARR-positive B cell enhancer mm9_chr5:152537120-152537217

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A1 is a growth-permissive antiapoptotic factor mediating postactivation survival in T cells. Gonzalez J, et al. Blood, 2003 Apr 1. PMID 12406903
    2. Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner. Gray S, et al. Cell Rep, 2020 Jul 7. PMID 32640224, Free PMC Article
    3. cDNAs encoding the large subunit of human replication factor C. Bunz F, et al. Proc Natl Acad Sci U S A, 1993 Dec 1. PMID 8248204, Free PMC Article
    4. Affinity purification strategies for proteomic analysis of transcription factor complexes. Giambruno R, et al. J Proteome Res, 2013 Sep 6. PMID 23937658, Free PMC Article
    5. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Grebien F, et al. Nat Chem Biol, 2015 Aug. PMID 26167872, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A1 is a growth-permissive antiapoptotic factor mediating postactivation survival in T cells.
      Title: A1 is a growth-permissive antiapoptotic factor mediating postactivation survival in T cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on DNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to DNA clamp loader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to DNA clamp loader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to DNA clamp loader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to single-stranded DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to single-stranded DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-directed DNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-directed DNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to organophosphorus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Ctf18 RFC-like complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Ctf18 RFC-like complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of DNA replication factor C complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DNA replication factor C complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    replication factor C subunit 3
    Names
    A1 38 kDa subunit
    RF-C 38 kDa subunit
    RFC38
    activator 1 38 kDa subunit
    activator 1 subunit 3
    replication factor C 3
    replication factor C 38 kDa subunit
    replication factor C, 38 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417694.1 → NP_001404623.1  replication factor C subunit 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC120011

    2. NM_001417695.1 → NP_001404624.1  replication factor C subunit 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC120011

    3. NM_027009.3 → NP_081285.1  replication factor C subunit 3 isoform 1

      See identical proteins and their annotated locations for NP_081285.1

      Status: VALIDATED

      Source sequence(s)
      AC120011
      Consensus CDS
      CCDS39413.1
      UniProtKB/Swiss-Prot
      Q8R323
      UniProtKB/TrEMBL
      Q3TKD1
      Related
      ENSMUSP00000039621.10, ENSMUST00000038131.10
      Conserved Domains (1) summary
      PRK12402
      Location:3 → 339
      PRK12402; replication factor C small subunit 2; Reviewed

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      151566282..151574673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254788.1 → XP_030110648.1  replication factor C subunit 3 isoform X1

      Conserved Domains (1) summary
      PRK12402
      Location:76 → 287
      PRK12402; replication factor C small subunit 2; Reviewed
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R323.1 GenPept UniProtKB/Swiss-Prot:Q8R323

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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