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    Grp gastrin releasing peptide [ Mus musculus (house mouse) ]

    Gene ID: 225642, updated on 9-Dec-2024

    Summary

    Official Symbol
    Grpprovided by MGI
    Official Full Name
    gastrin releasing peptideprovided by MGI
    Primary source
    MGI:MGI:95833
    See related
    Ensembl:ENSMUSG00000024517 AllianceGenome:MGI:95833
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BLP
    Summary
    This gene encodes a neuropeptide hormone that affects various biological processes such as neuroendocrine regulation, gastrointestinal secretion, nociception, cell proliferation and inflammation. The encoded protein undergoes proteolytic processing to generate multiple mature peptides with biological activity. [provided by RefSeq, Aug 2015]
    Expression
    Biased expression in stomach adult (RPKM 3.4), CNS E18 (RPKM 3.1) and 11 other tissues See more
    Orthologs
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    Genomic context

    See Grp in Genome Data Viewer
    Location:
    18 E1; 18 38.98 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (66005826..66019670)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (65872751..65886599)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:65960619-65960728 Neighboring gene STARR-positive B cell enhancer ABC_E1517 Neighboring gene STARR-positive B cell enhancer ABC_E9984 Neighboring gene STARR-positive B cell enhancer ABC_E1961 Neighboring gene SEC11 homolog C, signal peptidase complex subunit Neighboring gene STARR-seq mESC enhancer starr_44853 Neighboring gene predicted gene, 52375 Neighboring gene predicted gene, 30094 Neighboring gene predicted gene, 25150 Neighboring gene STARR-seq mESC enhancer starr_44855 Neighboring gene STARR-positive B cell enhancer ABC_E7598 Neighboring gene retina and anterior neural fold homeobox

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC37475

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables neuropeptide hormone activity  
    enables neuropeptide hormone activity  
    Process Evidence Code Pubs
    involved_in cellular response to sodium phosphate  
    involved_in mast cell degranulation PubMed 
    involved_in negative regulation of voltage-gated potassium channel activity  
    involved_in negative regulation of voltage-gated sodium channel activity  
    involved_in neuropeptide signaling pathway  
    acts_upstream_of_or_within neuropeptide signaling pathway  
    involved_in neuropeptide signaling pathway  
    involved_in ossification  
    involved_in ossification  
    involved_in positive regulation of behavioral fear response PubMed 
    involved_in positive regulation of peptide hormone secretion  
    involved_in positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway PubMed 
    involved_in positive regulation of respiratory gaseous exchange PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell apoptotic process  
    involved_in positive regulation of vascular associated smooth muscle cell apoptotic process  
    involved_in psychomotor behavior PubMed 
    involved_in regulation of gene expression  
    involved_in regulation of gene expression  
    involved_in response to external biotic stimulus PubMed 
    involved_in social behavior PubMed 
    Component Evidence Code Pubs
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in extracellular space  
    located_in neuron projection PubMed 
    located_in neuronal dense core vesicle  
    is_active_in neuronal dense core vesicle  
    located_in secretory granule lumen  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175012.4NP_778177.1  gastrin-releasing peptide preproprotein

      See identical proteins and their annotated locations for NP_778177.1

      Status: REVIEWED

      Source sequence(s)
      AK133508, AK139345, BE944748
      Consensus CDS
      CCDS29310.1
      UniProtKB/Swiss-Prot
      Q3UTL2, Q8R1I2
      Related
      ENSMUSP00000025395.9, ENSMUST00000025395.10
      Conserved Domains (1) summary
      pfam02044
      Location:4356
      Bombesin; Bombesin-like peptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      66005826..66019670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525886.5XP_006525949.1  gastrin-releasing peptide isoform X1

      See identical proteins and their annotated locations for XP_006525949.1

      UniProtKB/Swiss-Prot
      Q3UTL2, Q8R1I2
      Related
      ENSMUSP00000133437.2, ENSMUST00000173985.10
      Conserved Domains (1) summary
      pfam02044
      Location:4356
      Bombesin; Bombesin-like peptide
    2. XM_006525887.4XP_006525950.1  gastrin-releasing peptide isoform X2

      Conserved Domains (1) summary
      pfam02044
      Location:4356
      Bombesin; Bombesin-like peptide
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