Kcnk7 potassium channel, subfamily K, member 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnk7provided by MGI
Official Full Name: potassium channel, subfamily K, member 7provided by MGI
Primary source: MGI:MGI:1341841
See related: Ensembl:ENSMUSG00000024936 AllianceGenome:MGI:1341841
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Knot; Mlk3; Kcnk6; Kcnk8; 2310014G03Rik
Summary: Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; eye; genitourinary system; heart; and thymus. Orthologous to human KCNK7 (potassium two pore domain channel subfamily K member 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in stomach adult (RPKM 3.0), testis adult (RPKM 2.9) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.34 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (5754471..5757956)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (5704471..5707984)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that knockout mice (KCNK7-/-) display no difference in the minimum alveolar concentration (MAC) for the three volatile anesthetics compared to heterozygous (+/-) or wild-type (+/+). littermates.
Title: Knockout of the gene encoding the K(2P) channel KCNK7 does not alter volatile anesthetic sensitivity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484910

AI502630 (e-PCR)
- UniSTS:261724

Kcnk7 (e-PCR), detects polymorphism
- UniSTS:527059

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: potassium channel subfamily K member 7

Names: double-pore K(+) channel 3; neuromuscular two p domain potassium channel; putative potassium channel DP3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010609.4 → NP_034739.2 potassium channel subfamily K member 7 precursor

See identical proteins and their annotated locations for NP_034739.2

Status: VALIDATED

Source sequence(s)

AC134563

Consensus CDS

CCDS29477.1

UniProtKB/TrEMBL

Q3KNZ8, Q9JJ14

Related

ENSMUSP00000051278.4, ENSMUST00000052448.4

Conserved Domains (1) summary

pfam07885
Location:89 → 140

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

5754471..5757956

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006531666.5 → XP_006531729.1 potassium channel subfamily K member 7 isoform X1

See identical proteins and their annotated locations for XP_006531729.1

UniProtKB/TrEMBL

A0A494B9E8

Related

ENSMUSP00000157581.2, ENSMUST00000236818.2

Conserved Domains (1) summary

pfam07885
Location:88 → 115

Ion_trans_2; Ion channel

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001004138.1: Suppressed sequence

Description

NM_001004138.1: This RefSeq was permanently suppressed because it represents a poorly supported variant with non-consensus splice sites.