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    Tagln2 transgelin 2 [ Mus musculus (house mouse) ]

    Gene ID: 21346, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tagln2provided by MGI
    Official Full Name
    transgelin 2provided by MGI
    Primary source
    MGI:MGI:1312985
    See related
    Ensembl:ENSMUSG00000026547 AllianceGenome:MGI:1312985
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sm22B; Sm22a; SM22beta; 2700094C18Rik
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and epithelial cell differentiation. Predicted to be active in actin cytoskeleton. Is expressed in several structures, including autopod; cardiovascular system; gut; hemolymphoid system gland; and telencephalon ventricular layer. Orthologous to human TAGLN2 (transgelin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in stomach adult (RPKM 455.3), lung adult (RPKM 276.3) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tagln2 in Genome Data Viewer
    Location:
    1 H3; 1 79.89 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (172327813..172334942)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (172500246..172507375)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4391 Neighboring gene SLAM family member 9 Neighboring gene immunoglobulin superfamily, member 9 Neighboring gene STARR-positive B cell enhancer ABC_E2587 Neighboring gene STARR-positive B cell enhancer ABC_E9066 Neighboring gene STARR-seq mESC enhancer starr_03067 Neighboring gene STARR-positive B cell enhancer ABC_E7779 Neighboring gene cilia and flagella associated protein 45 Neighboring gene STARR-positive B cell enhancer mm9_chr1:174458799-174459099 Neighboring gene RIKEN cDNA 4933439K11 gene Neighboring gene STARR-seq mESC enhancer starr_03068 Neighboring gene V-set and immunoglobulin domain containing 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-phosphate-induced calcification is related to SM22α promoter methylation in vascular smooth muscle cells. Montes de Oca A, et al. J Bone Miner Res, 2010 Sep. PMID 20499380
    2. TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse. Na BR, et al. J Cell Biol, 2015 Apr 13. PMID 25869671, Free PMC Article
    3. Identification and verification of transgelin-2 as a potential biomarker of tumor-derived lung-cancer endothelial cells by comparative proteomics. Jin H, et al. J Proteomics, 2016 Mar 16. PMID 26721444
    4. Transgelin-2 in B-Cells Controls T-Cell Activation by Stabilizing T Cell - B Cell Conjugates. Na BR, et al. PLoS One, 2016. PMID 27232882, Free PMC Article
    5. Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy. Kim HR, et al. J Hematol Oncol, 2021 Mar 17. PMID 33731208, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MicroRNA133b alleviates doxorubicininduced cardiomyocyte apoptosis and cardiac fibrosis by targeting PTBP1 and TAGLN2.
      Title: MicroRNA‑133b alleviates doxorubicin‑induced cardiomyocyte apoptosis and cardiac fibrosis by targeting PTBP1 and TAGLN2.
    2. Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy.
      Title: Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy.
    3. Current findings highlight the contribution of cytoskeletal TAGLN2 to the obese phenotype in a gender-dependent manner
      Title: Cytoskeletal transgelin 2 contributes to gender-dependent adipose tissue expandability and immune function.
    4. An unidentified role of TAGLN2 in regulation of trophoblast invasion.
      Title: Transgelin 2 is required for embryo implantation by promoting actin polymerization.
    5. dual functional nature of TAGLN2-G-actin polymerization and Arp2/3 complex inhibition-may account for the mechanisms of filopodia development at the edge of Arp2/3-rich lamellipodia in various cell types
      Title: TAGLN2 polymerizes G-actin in a low ionic state but blocks Arp2/3-nucleated actin branching in physiological conditions.
    6. These results revealed a novel function of TAGLN2 as a molecular armament required for host defense.
      Title: An Essential Role for TAGLN2 in Phagocytosis of Lipopolysaccharide-activated Macrophages.
    7. transgelin-2 may also be involved in IS stability in B-cells, thereby influencing T-cell function
      Title: Transgelin-2 in B-Cells Controls T-Cell Activation by Stabilizing T Cell - B Cell Conjugates.
    8. All these results indicated a crucial role for Tagln2 in TECs for tumor development and metastasis.
      Title: Identification and verification of transgelin-2 as a potential biomarker of tumor-derived lung-cancer endothelial cells by comparative proteomics.
    9. A novel function of TAGLN2 in enhancing T cell responses by controlling actin stability at the immunological synapse.
      Title: TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse.
    10. The results indicate that miR-133b may play important roles in the growth and maturation of oocytes by regulating its potential target, TAGLN2, at both transcription and translation levels.
      Title: MiR-133b regulates the expression of the Actin protein TAGLN2 during oocyte growth and maturation: a potential target for infertility therapy.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0120

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transgelin-2
    Names
    SM22-beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178598.2 → NP_848713.1  transgelin-2

      See identical proteins and their annotated locations for NP_848713.1

      Status: VALIDATED

      Source sequence(s)
      AK151576
      Consensus CDS
      CCDS35784.1
      UniProtKB/Swiss-Prot
      Q3TIB8, Q6A0C6, Q78ZX2, Q91VU2, Q9WVA4
      Related
      ENSMUSP00000106861.2, ENSMUST00000111230.8
      Conserved Domains (3) summary
      COG5199
      Location:14 → 188
      SCP1; Calponin [Cytoskeleton]
      cd00014
      Location:25 → 136
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00402
      Location:174 → 197
      Calponin; Calponin family repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      172327813..172334942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WVA4.4 GenPept UniProtKB/Swiss-Prot:Q9WVA4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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