Rgs18 regulator of G-protein signaling 18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rgs18provided by MGI
Official Full Name: regulator of G-protein signaling 18provided by MGI
Primary source: MGI:MGI:1927498
See related: Ensembl:ENSMUSG00000026357 AllianceGenome:MGI:1927498
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables GTPase activator activity. Acts upstream of or within G protein-coupled receptor signaling pathway and regulation of G protein-coupled receptor signaling pathway. Located in cytoplasm. Is expressed in liver. Orthologous to human RGS18 (regulator of G protein signaling 18). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver E14 (RPKM 3.7), liver E18 (RPKM 2.8) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 F; 1 62.99 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (144628430..144651165, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (144752683..144775427, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A regulatory node involving Galphaq, PLCbeta, and RGS proteins modulates platelet reactivity to critical agonists.
Title: A regulatory node involving Gα(q), PLCβ, and RGS proteins modulates platelet reactivity to critical agonists.
RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival.
Title: RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival.
these results identify Rgs18 as a new and crucial effector of Gfi1b that regulates downstream signaling and gene expression programs to orchestrate erythro-megakaryocytic lineage choices.
Title: Reciprocal regulation of alternative lineages by Rgs18 and its transcriptional repressor Gfi1b.
Regulator of G-protein signaling 18 controls both platelet generation and function.
Title: Regulator of G-protein signaling 18 controls both platelet generation and function.
Regulated sequestration and release of RGS18 by intracellular binding proteins coordinates activating and inhibitory signaling networks in platelets. Substituting alanine for Ser94 blocks cAMP-induced dissociation of the SPL/RGS/SHP-1 complex.
Title: Modulating platelet reactivity through control of RGS18 availability.
RGS18 deficiency markedly shortened bleeding as well as occlusion times (in vivo). Furthermore, RGS18(-/-) platelets displayed hyper-responsiveness with regards to agonist induced aggregation
Title: The regulator of G-protein signaling 18 regulates platelet aggregation, hemostasis and thrombosis.
study is the first to show that RGS18 regulates megakaryopoiesis but also reveals its unexpected role in ciliogenesis, at least in lower vertebrates, via interference with Wnt signaling.
Title: Regulator of G-protein signaling 18 controls megakaryopoiesis and the cilia-mediated vertebrate mechanosensory system.
RGS18 acts as a negative regulator of the acidosis-induced osteoclastogenic protein-coupled receptor 68/NFAT signaling pathway
Title: RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rgs18 (e-PCR), detects polymorphism
- UniSTS:275690

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: regulator of G-protein signaling 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412709.1 → NP_001399638.1 regulator of G-protein signaling 18 isoform 2

Status: VALIDATED

Source sequence(s)

AC102163
NM_022881.6 → NP_075019.1 regulator of G-protein signaling 18 isoform 1

See identical proteins and their annotated locations for NP_075019.1

Status: VALIDATED

Source sequence(s)

AC102163

Consensus CDS

CCDS15350.1

UniProtKB/Swiss-Prot

Q99PG4

UniProtKB/TrEMBL

Q544K2

Related

ENSMUSP00000027603.4, ENSMUST00000027603.4

Conserved Domains (1) summary

cl02565
Location:87 → 199

RGS; Regulator of G protein signaling (RGS) domain superfamily