Mfap4 microfibrillar-associated protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mfap4provided by MGI
Official Full Name: microfibrillar-associated protein 4provided by MGI
Primary source: MGI:MGI:1342276
See related: Ensembl:ENSMUSG00000042436 AllianceGenome:MGI:1342276
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110007F23Rik
Summary: Predicted to be an extracellular matrix structural constituent. Predicted to be involved in elastic fiber assembly; regulation of collagen metabolic process; and response to UV. Located in collagen-containing extracellular matrix. Is expressed in brain; genitourinary system; heart and pericardium; and respiratory system mesenchyme. Orthologous to human MFAP4 (microfibril associated protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in lung adult (RPKM 558.6), limb E14.5 (RPKM 254.4) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B2; 11 37.96 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (61376257..61379536)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (61485431..61488708)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MFAP4-Deficiency Aggravates Age-Induced Changes in Resistance Artery Structure, While Ameliorating Hypertension.
Title: MFAP4-Deficiency Aggravates Age-Induced Changes in Resistance Artery Structure, While Ameliorating Hypertension.
Microfibrillar-Associated Protein 4 Regulates Stress-Induced Cardiac Remodeling.
Title: Microfibrillar-Associated Protein 4 Regulates Stress-Induced Cardiac Remodeling.
MFAP4 deficiency alleviates renal fibrosis through inhibition of NF-kappaB and TGF-beta/Smad signaling pathways.
Title: MFAP4 deficiency alleviates renal fibrosis through inhibition of NF-κB and TGF-β/Smad signaling pathways.
Deletion of Microfibrillar-Associated Protein 4 Attenuates Left Ventricular Remodeling and Dysfunction in Heart Failure.
Title: Deletion of Microfibrillar-Associated Protein 4 Attenuates Left Ventricular Remodeling and Dysfunction in Heart Failure.
An integrative systems approach identifies IGFBP-2, Mfap4, and Spp1 as novel candidates in Marfan syndrome-related pathophysiology.
Title: An integrative systems approach identifies novel candidates in Marfan syndrome-related pathophysiology.
MFAP4 promotes follicular dendritic cell development in regenerating splenic tissue.
Title: The role of microfibrillar-associated protein 4 (MFAP4) in the formation and function of splenic compartments during embryonic and adult life.
MFAP4 regulates integrin alphaVbeta3-induced VSMC proliferation and migration, as well as monocyte chemotaxis, and accelerates neointimal hyperplasia after vascular injury.
Title: MFAP4 Promotes Vascular Smooth Muscle Migration, Proliferation and Accelerates Neointima Formation.
MFAP4 promoted the development of asthmatic airway disease in vivo and pro-asthmatic functions of bronchial smooth muscle cells in vitro
Title: Microfibrillar-associated protein 4 modulates airway smooth muscle cell phenotype in experimental asthma.
Mfap4 knockout mice develop a spontaneous loss of lung function.
Title: Characterization of spontaneous air space enlargement in mice lacking microfibrillar-associated protein 4.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236597

UniSTS:469818 (e-PCR)
- UniSTS:469818

Mapk7 (e-PCR), detects polymorphism
- UniSTS:469818

AB019373 (e-PCR)
- UniSTS:163503

PMC324396P1 (e-PCR)
- UniSTS:273127

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in UV protection	IEA Inferred from Electronic Annotation more info
involved_in UV protection	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV-B	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV-B	ISO Inferred from Sequence Orthology more info
involved_in elastic fiber assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in elastic fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in elastic fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of collagen metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of collagen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in supramolecular fiber organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in elastic fiber	IEA Inferred from Electronic Annotation more info
located_in elastic fiber	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in microfibril	IEA Inferred from Electronic Annotation more info
located_in microfibril	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: microfibril-associated glycoprotein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347545.1 → NP_001334474.1 microfibril-associated glycoprotein 4 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AA270684, AL604029

Consensus CDS

CCDS83820.1

UniProtKB/Swiss-Prot

Q9D1H9

Related

ENSMUSP00000038971.7, ENSMUST00000040522.7
NM_001361359.1 → NP_001348288.1 microfibril-associated glycoprotein 4 isoform 3

Status: VALIDATED

Source sequence(s)

AL604029

Related

ENSMUST00000126308.2

Conserved Domains (1) summary

cd00087
Location:29 → 247

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
NM_029568.3 → NP_083844.1 microfibril-associated glycoprotein 4 isoform 2 precursor

See identical proteins and their annotated locations for NP_083844.1

Status: VALIDATED

Source sequence(s)

AL604029

Consensus CDS

CCDS24813.1

UniProtKB/Swiss-Prot

Q5NCN1, Q9D1H9

Related

ENSMUSP00000070848.4, ENSMUST00000064783.10

Conserved Domains (1) summary

cd00087
Location:38 → 256

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

61376257..61379536

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246411.2 → XP_030102271.1 microfibril-associated glycoprotein 4 isoform X1

Conserved Domains (1) summary

cd00087
Location:1 → 183

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...