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    Klhl23 kelch-like 23 [ Mus musculus (house mouse) ]

    Gene ID: 277396, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Klhl23provided by MGI
    Official Full Name
    kelch-like 23provided by MGI
    Primary source
    MGI:MGI:2683536
    See related
    Ensembl:ENSMUSG00000042155 AllianceGenome:MGI:2683536
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C130068N17Rik
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in embryo. Orthologous to human KLHL23 (kelch like family member 23). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 19.9), bladder adult (RPKM 14.6) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klhl23 in Genome Data Viewer
    Location:
    2 C2; 2 40.95 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (69652285..69666995)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (69821941..69836651)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13624 Neighboring gene predicted gene, 39841 Neighboring gene STARR-positive B cell enhancer mm9_chr2:69698414-69698714 Neighboring gene STARR-positive B cell enhancer ABC_E4462 Neighboring gene STARR-positive B cell enhancer ABC_E11134 Neighboring gene small RNA binding exonuclease protection factor La Neighboring gene methyltransferase 5, N6-adenosine Neighboring gene STARR-seq mESC enhancer starr_04746 Neighboring gene STARR-positive B cell enhancer ABC_E508 Neighboring gene ubiquitin protein ligase E3 component n-recognin 3 Neighboring gene STARR-seq mESC enhancer starr_04748 Neighboring gene STARR-positive B cell enhancer ABC_E9515 Neighboring gene STARR-seq mESC enhancer starr_04749 Neighboring gene STARR-seq mESC enhancer starr_04750

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • C130068N17Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360394.2 → NP_001347323.1  kelch-like protein 23

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 3 encode the same protein.
      Source sequence(s)
      AL845261
      Consensus CDS
      CCDS16100.1
      UniProtKB/Swiss-Prot
      A2AR06, Q6GQU2, Q8C840
      Conserved Domains (4) summary
      PHA03098
      Location:45 → 545
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:359 → 402
      Kelch; KELCH repeat [structural motif]
      cd18252
      Location:15 → 141
      BTB_POZ_KLHL23; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23)
      cd18462
      Location:134 → 235
      BACK_KLHL23; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23)

    2. NM_001360395.2 → NP_001347324.1  kelch-like protein 23

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 3 encode the same protein.
      Source sequence(s)
      AL845261
      Consensus CDS
      CCDS16100.1
      UniProtKB/Swiss-Prot
      A2AR06, Q6GQU2, Q8C840
      Conserved Domains (4) summary
      PHA03098
      Location:45 → 545
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:359 → 402
      Kelch; KELCH repeat [structural motif]
      cd18252
      Location:15 → 141
      BTB_POZ_KLHL23; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23)
      cd18462
      Location:134 → 235
      BACK_KLHL23; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23)

    3. NM_177784.5 → NP_808452.2  kelch-like protein 23

      See identical proteins and their annotated locations for NP_808452.2

      Status: VALIDATED

      Source sequence(s)
      AL845261
      Consensus CDS
      CCDS16100.1
      UniProtKB/Swiss-Prot
      A2AR06, Q6GQU2, Q8C840
      Related
      ENSMUSP00000050219.4, ENSMUST00000053087.4
      Conserved Domains (4) summary
      PHA03098
      Location:45 → 545
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:359 → 402
      Kelch; KELCH repeat [structural motif]
      cd18252
      Location:15 → 141
      BTB_POZ_KLHL23; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23)
      cd18462
      Location:134 → 235
      BACK_KLHL23; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      69652285..69666995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004940622.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6GQU2.1 GenPept UniProtKB/Swiss-Prot:Q6GQU2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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