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    Osbpl6 oxysterol binding protein-like 6 [ Mus musculus (house mouse) ]

    Gene ID: 99031, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Osbpl6provided by MGI
    Official Full Name
    oxysterol binding protein-like 6provided by MGI
    Primary source
    MGI:MGI:2139014
    See related
    Ensembl:ENSMUSG00000042359 AllianceGenome:MGI:2139014
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ORP-6; mKIAA4128; 1110062M20Rik
    Summary
    Predicted to enable cholesterol binding activity. Predicted to be involved in regulation of cholesterol transport. Predicted to be located in early endosome membrane and endoplasmic reticulum membrane. Predicted to be active in several cellular components, including cytosol; nuclear membrane; and perinuclear endoplasmic reticulum. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and hindlimb interdigital region. Orthologous to human OSBPL6 (oxysterol binding protein like 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in kidney adult (RPKM 4.2), lung adult (RPKM 3.2) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Osbpl6 in Genome Data Viewer
    Location:
    2 C3; 2 44.94 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (76236848..76430991)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (76406504..76600647)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cytochrome c, testis Neighboring gene RNA binding motif protein 45 Neighboring gene STARR-seq mESC enhancer starr_04893 Neighboring gene protein kinase, interferon inducible double stranded RNA dependent activator Neighboring gene pejvakin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Oxysterol-binding protein-related protein (ORP) 6 localizes to the ER and ER-plasma membrane contact sites and is involved in the turnover of PI4P in cerebellar granule neurons. Mochizuki S, et al. Exp Cell Res, 2018 Sep 15. PMID 30028970
    2. miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux. Ouimet M, et al. Arterioscler Thromb Vasc Biol, 2016 May. PMID 26941018, Free PMC Article
    3. An oxysterol-binding protein family identified in the mouse. Anniss AM, et al. DNA Cell Biol, 2002 Aug. PMID 12215260
    4. Understanding the development of oral epithelial organs through single cell transcriptomic analysis. Ye Q, et al. Development, 2022 Aug 15. PMID 35831953, Free PMC Article
    5. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4128, MGC30542

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein-related protein 6
    Names
    OSBP-related protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290733.1 → NP_001277662.1  oxysterol-binding protein-related protein 6 isoform b

      See identical proteins and their annotated locations for NP_001277662.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AI597353, AK044411, AL928867, BY704583, CJ104457
      Consensus CDS
      CCDS71078.1
      UniProtKB/Swiss-Prot
      Q8BXR9, Q8BYW2
      UniProtKB/TrEMBL
      Q5DTM2
      Related
      ENSMUSP00000107560.2, ENSMUST00000111929.8
      Conserved Domains (2) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:595 → 943
      Oxysterol_BP; Oxysterol-binding protein

    2. NM_001290734.1 → NP_001277663.1  oxysterol-binding protein-related protein 6 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in both the 5' and central coding regions, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
      Source sequence(s)
      AI597353, AK037703, AL928867, BY704583, CJ104457
      Consensus CDS
      CCDS71079.1
      UniProtKB/TrEMBL
      Q5DTM2
      Related
      ENSMUSP00000107561.3, ENSMUST00000111930.9
      Conserved Domains (2) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:564 → 912
      Oxysterol_BP; Oxysterol-binding protein

    3. NM_001290735.1 → NP_001277664.1  oxysterol-binding protein-related protein 6 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains alternate 5' and 3' terminal exons, and it lacks several 3' exons and thus differs in both UTRs and the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is significantly shorter than isoform a.
      Source sequence(s)
      AL928905, CJ098947
      Related
      ENSMUST00000128034.2

    4. NM_145525.3 → NP_663500.2  oxysterol-binding protein-related protein 6 isoform a

      See identical proteins and their annotated locations for NP_663500.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AI597353, AK044411, AL928867, AL928905, BY704583, CJ104457
      Consensus CDS
      CCDS16158.1
      UniProtKB/TrEMBL
      F8WIZ7, Q5DTM2
      Related
      ENSMUSP00000077123.5, ENSMUST00000077972.11
      Conserved Domains (2) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:603 → 951
      Oxysterol_BP; Oxysterol-binding protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      76236848..76430991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239862.3 → XP_011238164.1  oxysterol-binding protein-related protein 6 isoform X2

      See identical proteins and their annotated locations for XP_011238164.1

      UniProtKB/Swiss-Prot
      Q8BXR9, Q8BYW2
      UniProtKB/TrEMBL
      Q5DTM2
      Conserved Domains (2) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:595 → 943
      Oxysterol_BP; Oxysterol-binding protein

    2. XM_036162747.1 → XP_036018640.1  oxysterol-binding protein-related protein 6 isoform X6

      UniProtKB/TrEMBL
      Q5DTM2
      Conserved Domains (2) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:559 → 907
      Oxysterol_BP; Oxysterol-binding protein

    3. XM_011239864.3 → XP_011238166.1  oxysterol-binding protein-related protein 6 isoform X3

      UniProtKB/TrEMBL
      Q5DTM2
      Conserved Domains (2) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:578 → 926
      Oxysterol_BP; Oxysterol-binding protein

    4. XM_011239866.3 → XP_011238168.1  oxysterol-binding protein-related protein 6 isoform X5

      See identical proteins and their annotated locations for XP_011238168.1

      UniProtKB/TrEMBL
      Q5DTM2
      Related
      ENSMUSP00000139363.2, ENSMUST00000184442.2
      Conserved Domains (2) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:570 → 918
      Oxysterol_BP; Oxysterol-binding protein

    5. XM_036162748.1 → XP_036018641.1  oxysterol-binding protein-related protein 6 isoform X9

      UniProtKB/TrEMBL
      Q5DTM2
      Conserved Domains (2) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:534 → 882
      Oxysterol_BP; Oxysterol-binding protein

    6. XM_011239865.3 → XP_011238167.1  oxysterol-binding protein-related protein 6 isoform X4

      UniProtKB/TrEMBL
      Q5DTM2
      Conserved Domains (2) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:572 → 920
      Oxysterol_BP; Oxysterol-binding protein

    7. XM_011239867.3 → XP_011238169.1  oxysterol-binding protein-related protein 6 isoform X7

      UniProtKB/TrEMBL
      Q5DTM2
      Conserved Domains (2) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:547 → 895
      Oxysterol_BP; Oxysterol-binding protein

    8. XM_011239868.3 → XP_011238170.1  oxysterol-binding protein-related protein 6 isoform X8

      UniProtKB/TrEMBL
      Q5DTM2
      Conserved Domains (2) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:539 → 887
      Oxysterol_BP; Oxysterol-binding protein

    9. XM_036162749.1 → XP_036018642.1  oxysterol-binding protein-related protein 6 isoform X10

      UniProtKB/TrEMBL
      Q5DTM2
      Conserved Domains (2) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:503 → 851
      Oxysterol_BP; Oxysterol-binding protein

    10. XM_011239869.2 → XP_011238171.1  oxysterol-binding protein-related protein 6 isoform X11

      Conserved Domains (1) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain

    11. XM_036162751.1 → XP_036018644.1  oxysterol-binding protein-related protein 6 isoform X12

      Conserved Domains (1) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain

    12. XM_036162753.1 → XP_036018646.1  oxysterol-binding protein-related protein 6 isoform X14

      Conserved Domains (1) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain

    13. XM_036162752.1 → XP_036018645.1  oxysterol-binding protein-related protein 6 isoform X13

      Conserved Domains (1) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain

    14. XM_036162754.1 → XP_036018647.1  oxysterol-binding protein-related protein 6 isoform X15

      Conserved Domains (1) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain

    15. XM_011239859.2 → XP_011238161.1  oxysterol-binding protein-related protein 6 isoform X1

      See identical proteins and their annotated locations for XP_011238161.1

      UniProtKB/TrEMBL
      F8WIZ7, Q5DTM2
      Conserved Domains (2) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:603 → 951
      Oxysterol_BP; Oxysterol-binding protein

    16. XM_036162750.1 → XP_036018643.1  oxysterol-binding protein-related protein 6 isoform X10

      UniProtKB/TrEMBL
      Q5DTM2
      Conserved Domains (2) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:503 → 851
      Oxysterol_BP; Oxysterol-binding protein

    17. XM_011239860.2 → XP_011238162.1  oxysterol-binding protein-related protein 6 isoform X1

      See identical proteins and their annotated locations for XP_011238162.1

      UniProtKB/TrEMBL
      F8WIZ7, Q5DTM2
      Conserved Domains (2) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:603 → 951
      Oxysterol_BP; Oxysterol-binding protein

    18. XM_036162746.1 → XP_036018639.1  oxysterol-binding protein-related protein 6 isoform X1

      UniProtKB/TrEMBL
      F8WIZ7, Q5DTM2
      Conserved Domains (2) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:603 → 951
      Oxysterol_BP; Oxysterol-binding protein

    19. XM_030252270.1 → XP_030108130.1  oxysterol-binding protein-related protein 6 isoform X1

      UniProtKB/TrEMBL
      F8WIZ7, Q5DTM2
      Conserved Domains (2) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:603 → 951
      Oxysterol_BP; Oxysterol-binding protein

    20. XM_030252269.1 → XP_030108129.1  oxysterol-binding protein-related protein 6 isoform X1

      UniProtKB/TrEMBL
      F8WIZ7, Q5DTM2
      Conserved Domains (2) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:603 → 951
      Oxysterol_BP; Oxysterol-binding protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BXR9.1 GenPept UniProtKB/Swiss-Prot:Q8BXR9

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