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    Crls1 cardiolipin synthase 1 [ Mus musculus (house mouse) ]

    Gene ID: 66586, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Crls1provided by MGI
    Official Full Name
    cardiolipin synthase 1provided by MGI
    Primary source
    MGI:MGI:1913836
    See related
    Ensembl:ENSMUSG00000027357 AllianceGenome:MGI:1913836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610009I22Rik; 4930557M15Rik; 5730490M08Rik
    Summary
    Predicted to enable cardiolipin synthase (CMP-forming). Predicted to be involved in cardiolipin biosynthetic process; response to phosphatidylethanolamine; and response to thyroxine. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 57. Orthologous to human CRLS1 (cardiolipin synthase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 28.2), adrenal adult (RPKM 25.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Crls1 in Genome Data Viewer
    Location:
    2 F2; 2 64.77 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (132688557..132708706)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (132846650..132866786)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene chromogranin B Neighboring gene STARR-positive B cell enhancer ABC_E4502 Neighboring gene tRNA methyltransferase 6 Neighboring gene minichromosome maintenance 8 homologous recombination repair factor Neighboring gene STARR-positive B cell enhancer ABC_E10152 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:132672271-132672472 Neighboring gene leucine rich repeat neuronal 4 Neighboring gene predicted gene, 54154 Neighboring gene STARR-positive B cell enhancer ABC_E9534 Neighboring gene fermitin family member 1 Neighboring gene predicted gene 14102

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cardiolipin is essential for early embryonic viability and mitochondrial integrity of neurons in mammals. Kasahara T, et al. FASEB J, 2020 Jan. PMID 31914590
    2. Age-dependent loss of Crls1 causes myopathy and skeletal muscle regeneration failure. Yoo Y, et al. Exp Mol Med, 2024 Apr. PMID 38556544, Free PMC Article
    3. Shotgun lipidomics reveals the temporally dependent, highly diversified cardiolipin profile in the mammalian brain: temporally coordinated postnatal diversification of cardiolipin molecular species with neuronal remodeling. Cheng H, et al. Biochemistry, 2008 May 27. PMID 18454555, Free PMC Article
    4. Cardiolipin Synthase 1 Ameliorates NASH Through Activating Transcription Factor 3 Transcriptional Inactivation. Tu C, et al. Hepatology, 2020 Dec. PMID 32096565
    5. Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis. Sustarsic EG, et al. Cell Metab, 2018 Jul 3. PMID 29861389, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Age-dependent loss of Crls1 causes myopathy and skeletal muscle regeneration failure.
      Title: Age-dependent loss of Crls1 causes myopathy and skeletal muscle regeneration failure.
    2. Cardiolipin Synthase 1 Ameliorates NASH Through Activating Transcription Factor 3 Transcriptional Inactivation.
      Title: Cardiolipin Synthase 1 Ameliorates NASH Through Activating Transcription Factor 3 Transcriptional Inactivation.
    3. transgenic expression of cardiolipin synthase attenuated maladaptive cardiolipin remodeling and bioenergetic inefficiency in myocardium rendered diabetic by streptozotocin treatment.
      Title: Myocardial regulation of lipidomic flux by cardiolipin synthase: setting the beat for bioenergetic efficiency.
    4. CLS mRNA levels cannot be correlated with CLS enzyme activity nor CL content in the LPS model of inflammation.
      Title: Cardiolipin synthase-1 mRNA expression does not correlate with endogenous cardiolipin synthase enzyme activity in vitro and in vivo in mammalian lipopolysaccharide models of inflammation.
    5. CL has roles in in neuronal signaling, mitochondrial bioenergetics, and apoptosis
      Title: Shotgun lipidomics reveals the temporally dependent, highly diversified cardiolipin profile in the mammalian brain: temporally coordinated postnatal diversification of cardiolipin molecular species with neuronal remodeling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cardiolipin synthase (CMP-forming) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cardiolipin synthase (CMP-forming) ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cardiolipin synthase (CMP-forming) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiolipin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiolipin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiolipin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to phosphatidylethanolamine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to phosphatidylethanolamine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to thyroxine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to thyroxine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cardiolipin synthase (CMP-forming)
    Names
    CLS
    NP_001019556.1
    NP_079922.2
    XP_006500075.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024385.1 → NP_001019556.1  cardiolipin synthase (CMP-forming) isoform 1

      See identical proteins and their annotated locations for NP_001019556.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK018180, BC048702, BC086619
      Consensus CDS
      CCDS16779.1
      UniProtKB/Swiss-Prot
      Q80ZM8, Q9D4U1
      Related
      ENSMUSP00000028835.7, ENSMUST00000028835.13
      Conserved Domains (1) summary
      COG0558
      Location:108 → 298
      PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]

    2. NM_025646.3 → NP_079922.2  cardiolipin synthase (CMP-forming) isoform 2

      See identical proteins and their annotated locations for NP_079922.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon and the translation initiates from a downstream AUG codon, as compared to variant 1. The encoded isoform 2 has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK016165, BC086619
      Consensus CDS
      CCDS38247.1
      UniProtKB/TrEMBL
      A0A0C3SFZ5, E9PYF8
      Related
      ENSMUSP00000132682.2, ENSMUST00000124836.8
      Conserved Domains (1) summary
      PLN02794
      Location:1 → 174
      PLN02794; cardiolipin synthase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      132688557..132708706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500012.3 → XP_006500075.1  cardiolipin synthase (CMP-forming) isoform X1

      See identical proteins and their annotated locations for XP_006500075.1

      UniProtKB/TrEMBL
      E9PYF8
      Related
      ENSMUSP00000129137.2, ENSMUST00000154160.2
      Conserved Domains (1) summary
      PLN02794
      Location:10 → 189
      PLN02794; cardiolipin synthase

    RNA

    1. XR_866333.4 RNA Sequence

      Related
      ENSMUST00000124834.8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001024384.1: Suppressed sequence

      Description
      NM_001024384.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80ZM8.1 GenPept UniProtKB/Swiss-Prot:Q80ZM8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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