Hmgn2 high mobility group nucleosomal binding domain 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hmgn2provided by MGI
Official Full Name: high mobility group nucleosomal binding domain 2provided by MGI
Primary source: MGI:MGI:96136
See related: Ensembl:ENSMUSG00000003038 AllianceGenome:MGI:96136
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hmg17; HMG-17
Summary: Predicted to enable chromatin binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II and regulation of development, heterochronic. Located in female germ cell nucleus. Is expressed in several structures, including brain; eye; genitourinary system; heart; and lung. Used to study Axenfeld-Rieger syndrome type 1. Orthologous to human HMGN2 (high mobility group nucleosomal binding domain 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E11.5 (RPKM 375.6), limb E14.5 (RPKM 204.2) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.3; 4 66.47 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (133692050..133695302, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (133964739..133967991, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epigenetic Regulation of Ameloblast Differentiation by HMGN Proteins.
Title: Epigenetic Regulation of Ameloblast Differentiation by HMGN Proteins.
HMGN2 represses gene transcription via interaction with transcription factors Lef-1 and Pitx2 during amelogenesis.
Title: HMGN2 represses gene transcription via interaction with transcription factors Lef-1 and Pitx2 during amelogenesis.
The regulatory effect of acetylation of HMGN2 and H3K27 on pyocyanin-induced autophagy in macrophages by affecting Ulk1 transcription.
Title: The regulatory effect of acetylation of HMGN2 and H3K27 on pyocyanin-induced autophagy in macrophages by affecting Ulk1 transcription.
HMGN2 regulates non-tuberculous mycobacteria survival via modulation of M1 macrophage polarization.
Title: HMGN2 regulates non-tuberculous mycobacteria survival via modulation of M1 macrophage polarization.
High-mobility group nucleosomal binding domain 2 protects against microcephaly by maintaining global chromatin accessibility during corticogenesis.
Title: High-mobility group nucleosomal binding domain 2 protects against microcephaly by maintaining global chromatin accessibility during corticogenesis.
Urinary tract infection is one of the most common bacterial infections which is mainly caused by Escherichia coli (UPEC). HMGN2 expression is elevated in UPEC J96 infected C57BL/6J mice and bladder epithelial cell line 5637 (BEC 5637). HMGN2 induces autophagy in BEC 5637 via AMPK/ULK1 pathway.
Title: High-mobility group protein N2 induces autophagy by activating AMPK/ULK1 pathway and thereby boosts UPEC proliferation within bladder epithelial cells.
High mobility group nucleosomal binding proteins HMGN1 and HMGN2 proteins modulate the plasticity of the chromatin epigenetic landscape thereby stabilizing, rather than determining cell identity.
Title: Binding of HMGN proteins to cell specific enhancers stabilizes cell identity.
Knockdown of Hmgn2 blocked the progesterone-induced differentiation of uterine stromal cells. Hmgn2 mediates the effects of estrogen on the expression of Cdh1, Cdh2 and Ctnnb1 in uterine epithelial cells.
Title: Evidence For Hmgn2 Involvement in Mouse Embryo Implantation and Decidualization.
study demonstrates a role of HMGN2 in modulating specific gene expression and identifies beta-defensin-1, beta-defensin-3, and beta-defensin-4 as HMGN2 targets during the development of ICR mice treated with LPS
Title: The chromosomal protein HMGN2 mediates the LPS-induced expression of β-defensins in mice.
The ectopic expression of Hmgn2 antagonizes mouse erythroid differentiation in vitro, which may be due to enhancement of DNA replication and/or blocking entry of mitosis at S-phase.
Title: Ectopic expression of Hmgn2 antagonizes mouse erythroid differentiation in vitro.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hmgn2 (e-PCR), detects polymorphism
- UniSTS:547638

Hmgn2 (e-PCR), detects polymorphism
- UniSTS:143351

Clone Names

MGC102472, MGC103137, MGC103384, MGC118420

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleosomal DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of development, heterochronic	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in female germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: non-histone chromosomal protein HMG-17

Names: high mobility group nucleosome-binding domain-containing protein 2; high mobility group protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.