Kif22 kinesin family member 22 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif22provided by MGI
Official Full Name: kinesin family member 22provided by MGI
Primary source: MGI:MGI:109233
See related: Ensembl:ENSMUSG00000030677 AllianceGenome:MGI:109233
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kid; Kif22a
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement; mitotic metaphase chromosome alignment; and sister chromatid cohesion. Located in chromatin and spindle. Is expressed in cerebral cortex ventricular layer; cortical plate; and inner cell mass. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia with joint laxity type 2. Orthologous to human KIF22 (kinesin family member 22). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E11.5 (RPKM 35.8), liver E14 (RPKM 33.5) and 13 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 7 F3; 7 69.29 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (126626901..126641639, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (127027729..127042467, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

phosphorylation of Thr463 switches the mitotic chromosome movement from an anti-poleward direction to a poleward direction by converting the Kid functional mode from polar-ejection-force-ON to -OFF during the metaphase-anaphase transition.
Title: The microtubule-binding and coiled-coil domains of Kid are required to turn off the polar ejection force at anaphase.
These data suggest that Kid-mediated anaphase/telophase chromosome compaction prevents formation of multinucleated cells.
Title: Kid-mediated chromosome compaction ensures proper nuclear envelope formation.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH124205 (e-PCR)
- UniSTS:161027

NoName (e-PCR)
- UniSTS:235784

NoName (e-PCR)
- UniSTS:235787

C81217 (e-PCR)
- UniSTS:208209

RH126899 (e-PCR)
- UniSTS:208210

RH127033 (e-PCR)
- UniSTS:208211

D7Ertd807e (e-PCR), detects polymorphism
- UniSTS:167552

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in metaphase chromosome alignment	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic metaphase chromosome alignment	ISS Inferred from Sequence or Structural Similarity more info
involved_in sister chromatid cohesion	ISO Inferred from Sequence Orthology more info
involved_in sister chromatid cohesion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: kinesin-like protein KIF22

Names: kinesin family member 22A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001403623.1 → NP_001390552.1 kinesin-like protein KIF22 isoform 2

Status: VALIDATED

Source sequence(s)

AC122863
NM_145588.2 → NP_663563.1 kinesin-like protein KIF22 isoform 1

See identical proteins and their annotated locations for NP_663563.1

Status: VALIDATED

Source sequence(s)

AC122863

Consensus CDS

CCDS21855.1

UniProtKB/Swiss-Prot

O35232, Q3V300, Q99LC7

Related

ENSMUSP00000032915.7, ENSMUST00000032915.8

Conserved Domains (3) summary

smart00129
Location:38 → 370

KISc; Kinesin motor, catalytic domain. ATPase

cd01376
Location:38 → 361

KISc_KID_like; Kinesin motor domain, KIF22/Kid-like subgroup

pfam12836
Location:591 → 641

HHH_3; Helix-hairpin-helix motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

126626901..126641639 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507201.2 → XP_006507264.1 kinesin-like protein KIF22 isoform X1

Conserved Domains (2) summary

cd01376
Location:38 → 361

KISc_KID_like; Kinesin motor domain, KIF22/Kid-like subgroup

cl39090
Location:591 → 641

ComEA; DNA uptake protein ComE and related DNA-binding proteins [Replication, recombination and repair]