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    Acot9 acyl-CoA thioesterase 9 [ Mus musculus (house mouse) ]

    Gene ID: 56360, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Acot9provided by MGI
    Official Full Name
    acyl-CoA thioesterase 9provided by MGI
    Primary source
    MGI:MGI:1928939
    See related
    Ensembl:ENSMUSG00000025287 AllianceGenome:MGI:1928939
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    U8; p48; MTE-2; Acate2; MT-ACT48; 0610041P13Rik
    Summary
    Enables acetyl-CoA hydrolase activity and long-chain fatty acyl-CoA hydrolase activity. Involved in acyl-CoA metabolic process; long-chain fatty acid metabolic process; and short-chain fatty acid metabolic process. Located in mitochondrial matrix. Is expressed in cortical plate; dorsal root ganglion; trigeminal ganglion; and vagus ganglion. Orthologous to human ACOT9 (acyl-CoA thioesterase 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 15.0), placenta adult (RPKM 10.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Acot9 in Genome Data Viewer
    Location:
    X F3; X 72.38 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (154045439..154080650)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (155262443..155297654)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene spermidine/spermine N1-acetyl transferase 1 Neighboring gene ribosomal protein L7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_48136 Neighboring gene peroxiredoxin 4 Neighboring gene predicted gene, 39545 Neighboring gene predicted gene, 57670

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Acyl-CoA thioesterase 9 (ACOT9) in mouse may provide a novel link between fatty acid and amino acid metabolism in mitochondria. Tillander V, et al. Cell Mol Life Sci, 2014 Mar. PMID 23864032, Free PMC Article
    2. Multiple mitochondrial thioesterases have distinct tissue and substrate specificity and CoA regulation, suggesting unique functional roles. Bekeova C, et al. J Biol Chem, 2019 Dec 13. PMID 31676684, Free PMC Article
    3. Molecular cloning and characterization of MT-ACT48, a novel mitochondrial acyl-CoA thioesterase. Poupon V, et al. J Biol Chem, 1999 Jul 2. PMID 10383425
    4. Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring leading to altered fatty acid sensing and increased intake of high-fat food. Dearden L, et al. PLoS Biol, 2024 Jun. PMID 38833481, Free PMC Article
    5. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. Hunt MC, et al. J Lipid Res, 2005 Sep. PMID 16103133

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Acyl-CoA thioesterase 9 (ACOT9) in mouse may provide a novel link between fatty acid and amino acid metabolism in mitochondria.
      Title: Acyl-CoA thioesterase 9 (ACOT9) in mouse may provide a novel link between fatty acid and amino acid metabolism in mitochondria.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetyl-CoA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acyl-CoA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables long-chain fatty acyl-CoA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in short-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acyl-coenzyme A thioesterase 9, mitochondrial
    Names
    acyl coenzyme A thioester hydrolase 2
    acyl-CoA thioester hydrolase 9
    acyl-Coenzyme A thioesterase 2, mitochondrial
    mitochondrial 48 kDa acyl-CoA thioester hydrolase 1
    mitochondrial acyl-CoA thioesterase
    protein U8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313718.1 → NP_001300647.1  acyl-coenzyme A thioesterase 9, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' end, which causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AI854821, AK076513, BY288219
      Conserved Domains (1) summary
      PLN02647
      Location:3 → 336
      PLN02647; acyl-CoA thioesterase

    2. NM_019736.4 → NP_062710.2  acyl-coenzyme A thioesterase 9, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_062710.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AI854821, AK168713, BY288219
      Consensus CDS
      CCDS41187.1
      UniProtKB/Swiss-Prot
      Q545G7, Q9R0X4, Q9WTJ0, Q9WUZ8
      Related
      ENSMUSP00000026324.10, ENSMUST00000026324.10
      Conserved Domains (1) summary
      cd03442
      Location:286 → 406
      BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      154045439..154080650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251411.2 → XP_030107271.1  acyl-coenzyme A thioesterase 9, mitochondrial isoform X1

      Conserved Domains (1) summary
      PLN02647
      Location:3 → 336
      PLN02647; acyl-CoA thioesterase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R0X4.1 GenPept UniProtKB/Swiss-Prot:Q9R0X4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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