Rnf41 ring finger protein 41 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnf41provided by MGI
Official Full Name: ring finger protein 41provided by MGI
Primary source: MGI:MGI:1914838
See related: Ensembl:ENSMUSG00000025373 AllianceGenome:MGI:1914838
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FLRF; Nrdp1; D10Ertd722e; 2210404G21Rik; 4930511A05Rik; 4933415P08Rik
Summary: Enables erythropoietin receptor binding activity and interleukin-3 receptor binding activity. Acts upstream of or within negative regulation of mitophagy; protein polyubiquitination; and regulation of hemopoiesis. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in endoplasmic reticulum tubular network. Is expressed in several structures, including central nervous system; dorsal root ganglion; male reproductive system; and urinary system. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human RNF41 (ring finger protein 41). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 22.7), CNS E18 (RPKM 16.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 76.55 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (128247485..128277310)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (128411616..128441441)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VEGF-induced Nrdp1 deficiency in vascular endothelial cells promotes cancer metastasis by degrading vascular basement membrane.
Title: VEGF-induced Nrdp1 deficiency in vascular endothelial cells promotes cancer metastasis by degrading vascular basement membrane.
Nrdp1-mediated Macrophage Phenotypic Regulation Promotes Functional Recovery in Mice with Mild Neurological Impairment after Intracerebral Hemorrhage.
Title: Nrdp1-mediated Macrophage Phenotypic Regulation Promotes Functional Recovery in Mice with Mild Neurological Impairment after Intracerebral Hemorrhage.
Correlation between neuregulin receptor degradation protein-1 and Crohn's disease.
Title: Correlation between neuregulin receptor degradation protein-1 and Crohn's disease.
Ubiquitin Ligase Nrdp1 Controls Autophagy-Associated Acrosome Biogenesis and Mitochondrial Arrangement during Spermiogenesis.
Title: Ubiquitin Ligase Nrdp1 Controls Autophagy-Associated Acrosome Biogenesis and Mitochondrial Arrangement during Spermiogenesis.
RNF41 orchestrates macrophage-driven fibrosis resolution and hepatic regeneration.
Title: RNF41 orchestrates macrophage-driven fibrosis resolution and hepatic regeneration.
A20/Nrdp1 interaction alters the inflammatory signaling profile by mediating K48- and K63-linked polyubiquitination of effectors MyD88 and TBK1.
Title: A20/Nrdp1 interaction alters the inflammatory signaling profile by mediating K48- and K63-linked polyubiquitination of effectors MyD88 and TBK1.
RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells.
Title: RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells.
Data suggest that ring finger protein 41 Nrdp1 terminates T cell antigen receptors (TCRs) signaling by inactivating Zap70 kinase.
Title: K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8(+) T cell activation.
The novel Pdx1-Clec16a-Nrdp1 pathway this study describes provides a genetic basis for the pathogenesis of mitochondrial dysfunction in multiple forms of diabetes.
Title: Diabetes Susceptibility Genes Pdx1 and Clec16a Function in a Pathway Regulating Mitophagy in β-Cells.
Nrdp1 may be a key mediator in the development of cardiac dysfunction after DOX treatment and associated with inhibition of Akt, ERK1/2 and STAT3.
Title: Overexpression of Nrdp1 in the heart exacerbates doxorubicin-induced cardiac dysfunction in mice.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Gene trapped (1)
Transgenic (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136255 (e-PCR)
- UniSTS:210249

D10Ertd722e (e-PCR), detects polymorphism
- UniSTS:167033

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables erythropoietin receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables interleukin-3 receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mitophagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of lymphocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of myeloid cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum tubular network	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum tubular network	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum tubular network	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase NRDP1

Names: RING-type E3 ubiquitin transferase NRDP1

NP_001157709.1

EC 2.3.2.27

NP_080535.2

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164237.1 → NP_001157709.1 E3 ubiquitin-protein ligase NRDP1

See identical proteins and their annotated locations for NP_001157709.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript which encodes a functional protein.

Source sequence(s)

AK028551, AK045760, BC049078

Consensus CDS

CCDS24277.1

UniProtKB/Swiss-Prot

Q8BGJ2, Q8BH75, Q8BMC9, Q8VEA2, Q9CRK6, Q9D568

Related

ENSMUSP00000100869.4, ENSMUST00000096386.13

Conserved Domains (2) summary

cd16634
Location:15 → 57

mRING-HC-C3HC3D_Nrdp1; Modified RING finger, HC subclass (C3HC3D-type), found in neuregulin receptor degradation protein-1 (Nrdp1) and similar proteins

pfam08941
Location:137 → 315

USP8_interact; USP8 interacting
NM_026259.3 → NP_080535.2 E3 ubiquitin-protein ligase NRDP1

See identical proteins and their annotated locations for NP_080535.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an internal segment in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK045760, BC049078

Consensus CDS

CCDS24277.1

UniProtKB/Swiss-Prot

Q8BGJ2, Q8BH75, Q8BMC9, Q8VEA2, Q9CRK6, Q9D568

Related

ENSMUSP00000132751.2, ENSMUST00000171342.3

Conserved Domains (2) summary

cd16634
Location:15 → 57

mRING-HC-C3HC3D_Nrdp1; Modified RING finger, HC subclass (C3HC3D-type), found in neuregulin receptor degradation protein-1 (Nrdp1) and similar proteins

pfam08941
Location:137 → 315

USP8_interact; USP8 interacting

RNA

NR_104288.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK028551, AK045760, BC049078
NR_104289.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK028551, AK031657, AK045760, BC049078
NR_104290.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5) has an alternate internal exon in the 5' region and lacks an internal segment in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK016825, AK028551, AK045760, BC049078