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    Myh13 myosin, heavy polypeptide 13, skeletal muscle [ Mus musculus (house mouse) ]

    Gene ID: 544791, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Myh13provided by MGI
    Official Full Name
    myosin, heavy polypeptide 13, skeletal muscleprovided by MGI
    Primary source
    MGI:MGI:1339967
    See related
    Ensembl:ENSMUSG00000060180 AllianceGenome:MGI:1339967
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MyHC-eo
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within cellular response to starvation. Located in myofibril. Orthologous to human MYH13 (myosin heavy chain 13). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 3.6), limb E14.5 (RPKM 1.6) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Myh13 in Genome Data Viewer
    Location:
    11 B3; 11 40.85 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (67217929..67262413)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67327103..67371587)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene myosin, heavy polypeptide 4, skeletal muscle Neighboring gene STARR-seq mESC enhancer starr_29797 Neighboring gene nuclear encoded tRNA proline 2 (anticodon TGG) Neighboring gene myosin, heavy polypeptide 8, skeletal muscle, perinatal Neighboring gene STARR-seq mESC enhancer starr_29799 Neighboring gene STARR-seq mESC enhancer starr_29800 Neighboring gene predicted gene, 40029 Neighboring gene predicted gene, 31459 Neighboring gene STARR-seq mESC enhancer starr_29801 Neighboring gene growth arrest specific 7 Neighboring gene STARR-positive B cell enhancer ABC_E10680 Neighboring gene predicted gene 12301

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MYH13, a superfast myosin expressed in extraocular, laryngeal and syringeal muscles. Schiaffino S, et al. J Physiol, 2024 Feb. PMID 38160435
    2. The human extraocular muscle myosin heavy chain gene (MYH13) maps to the cluster of fast and developmental myosin genes on chromosome 17. Winters LM, et al. Genomics, 1998 Nov 15. PMID 9806854
    3. A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes. Dos Santos M, et al. Nat Commun, 2022 Feb 24. PMID 35210422, Free PMC Article
    4. Inhibition of atrogin-1/MAFbx mediated MyoD proteolysis prevents skeletal muscle atrophy in vivo. Lagirand-Cantaloube J, et al. PLoS One, 2009. PMID 19319192, Free PMC Article
    5. Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved. Weiss A, et al. Proc Natl Acad Sci U S A, 1999 Mar 16. PMID 10077619, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MYH13, a superfast myosin expressed in extraocular, laryngeal and syringeal muscles.
      Title: MYH13, a superfast myosin expressed in extraocular, laryngeal and syringeal muscles.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in myofibril IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in myosin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myosin-13
    Names
    EO Myosin
    extraocular myosin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081250.2 → NP_001074719.1  myosin-13

      Status: VALIDATED

      Source sequence(s)
      AL596255, BX255958
      Consensus CDS
      CCDS36185.1
      UniProtKB/TrEMBL
      B1AR69
      Related
      ENSMUSP00000080584.6, ENSMUST00000081911.12
      Conserved Domains (6) summary
      cd14923
      Location:100 → 770
      MYSc_Myh13; class II myosin heavy chain 13, motor domain
      pfam00063
      Location:88 → 770
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:850 → 1927
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:36 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam07851
      Location:1744 → 1837
      TMPIT; TMPIT-like protein
      cl19219
      Location:1506 → 1582
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      67217929..67262413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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