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    Gpr137c G protein-coupled receptor 137C [ Mus musculus (house mouse) ]

    Gene ID: 70713, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr137cprovided by MGI
    Official Full Name
    G protein-coupled receptor 137Cprovided by MGI
    Primary source
    MGI:MGI:1917963
    See related
    Ensembl:ENSMUSG00000049092 AllianceGenome:MGI:1917963
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm908; TM7SF1L2; 6330416L11Rik
    Summary
    Predicted to be involved in positive regulation of TORC1 signaling. Predicted to be active in lysosomal membrane. Orthologous to human GPR137C (G protein-coupled receptor 137C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 4.5), whole brain E14.5 (RPKM 3.6) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpr137c in Genome Data Viewer
    Location:
    14 C1; 14 22.82 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (45457142..45520192)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (45219685..45282735)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 16 Neighboring gene predicted gene, 34362 Neighboring gene STARR-positive B cell enhancer ABC_E95 Neighboring gene tubulin, beta 6 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr14:45861577-45861878 Neighboring gene endoplasmic reticulum oxidoreductase 1 alpha Neighboring gene STARR-positive B cell enhancer ABC_E3110 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:45949463-45949646 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase, 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    G protein-coupled receptor 137C
    Names
    G protein-coupled receptor TM7SF1L2
    integral membrane protein GPR137C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027518.2 → NP_081794.2  G protein-coupled receptor 137C

      Status: VALIDATED

      Source sequence(s)
      AC154575
      Consensus CDS
      CCDS49464.1
      UniProtKB/Swiss-Prot
      E9Q343
      Related
      ENSMUSP00000120015.2, ENSMUST00000146150.3
      Conserved Domains (2) summary
      cd21464
      Location:44 → 66
      7tm_GPR137; TM helix 1 [structural motif]
      cl28897
      Location:36 → 357
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      45457142..45520192
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519544.4 → XP_006519607.1  G protein-coupled receptor 137C isoform X1

    2. XM_017316191.3 → XP_017171680.1  G protein-coupled receptor 137C isoform X3

      UniProtKB/TrEMBL
      A0A2I3BPD5, A0A2I3BPS9
      Related
      ENSMUSP00000153737.2, ENSMUST00000227009.2

    3. XM_017316190.2 → XP_017171679.1  G protein-coupled receptor 137C isoform X2

      UniProtKB/TrEMBL
      A0A2I3BPS9
      Related
      ENSMUSP00000153906.2, ENSMUST00000227056.2

    4. XM_017316192.2 → XP_017171681.1  G protein-coupled receptor 137C isoform X4

      UniProtKB/TrEMBL
      A0A2I3BPS9

    RNA

    1. XR_004938445.1 RNA Sequence

    2. XR_874367.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q343.1 GenPept UniProtKB/Swiss-Prot:E9Q343

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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