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    Cryzl1 crystallin zeta like 1 [ Mus musculus (house mouse) ]

    Gene ID: 66609, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cryzl1provided by MGI
    Official Full Name
    crystallin zeta like 1provided by MGI
    Primary source
    MGI:MGI:1913859
    See related
    Ensembl:ENSMUSG00000058240 AllianceGenome:MGI:1913859
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    QOH-1; 2210407J23Rik; 2410006O11Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to be located in early endosome. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human CRYZL1 (crystallin zeta like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 16.6), CNS E14 (RPKM 13.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cryzl1 in Genome Data Viewer
    Location:
    16 C4; 16 53.26 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (91486210..91525690, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (91689300..91729206, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36712 Neighboring gene Son DNA binding protein Neighboring gene STARR-positive B cell enhancer ABC_E2468 Neighboring gene downstream neighbor of SON Neighboring gene predicted gene 10785 Neighboring gene predicted gene, 46543 Neighboring gene intersectin 1 (SH3 domain protein 1A) Neighboring gene predicted gene, 53921 Neighboring gene predicted gene, 52262

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855
    2. Human chromosome 21 gene expression atlas in the mouse. Reymond A, et al. Nature, 2002 Dec 5. PMID 12466854
    3. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
    4. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    quinone oxidoreductase-like protein 1
    Names
    crystallin, zeta (quinone reductase)-like 1
    ferry endosomal RAB5 effector complex subunit 4
    quinone oxidoreductase homolog 1
    zeta-crystallin homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026994.1 → NP_081270.1  quinone oxidoreductase-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_081270.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC131691
      Consensus CDS
      CCDS57039.1
      UniProtKB/TrEMBL
      D3YZD6, D3Z6I4
      Related
      ENSMUSP00000113227.2, ENSMUST00000117644.8
      Conserved Domains (2) summary
      cd05195
      Location:31 → 331
      enoyl_red; enoyl reductase of polyketide synthase
      COG0604
      Location:1 → 310
      Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

    2. NM_133679.2 → NP_598440.1  quinone oxidoreductase-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_598440.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK145827, BU757748, BY717916
      Consensus CDS
      CCDS37401.1
      UniProtKB/Swiss-Prot
      Q3UKX2, Q8VCS1, Q921W4, Q9CWR9
      UniProtKB/TrEMBL
      D3YZD6
      Related
      ENSMUSP00000073171.7, ENSMUST00000073466.13
      Conserved Domains (1) summary
      cd05195
      Location:31 → 346
      enoyl_red; enoyl reductase of polyketide synthase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      91486210..91525690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q921W4.1 GenPept UniProtKB/Swiss-Prot:Q921W4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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