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    Piezo2 piezo-type mechanosensitive ion channel component 2 [ Mus musculus (house mouse) ]

    Gene ID: 667742, updated on 10-Dec-2024

    Summary

    Official Symbol
    Piezo2provided by MGI
    Official Full Name
    piezo-type mechanosensitive ion channel component 2provided by MGI
    Primary source
    MGI:MGI:1918781
    See related
    Ensembl:ENSMUSG00000041482 AllianceGenome:MGI:1918781
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam38b; Fam38b2; 5930434P17; 9030411M15Rik; 9430028L06Rik
    Summary
    Enables mechanosensitive monoatomic ion channel activity and monoatomic cation channel activity. Involved in detection of mechanical stimulus involved in sensory perception and monoatomic cation transport. Acts upstream of or within regulation of membrane potential. Located in cuticular plate; neuronal cell body membrane; and stereocilium. Is expressed in dorsal root ganglion and lung. Human ortholog(s) of this gene implicated in distal arthrogryposis type 3 and distal arthrogryposis type 5. Orthologous to human PIEZO2 (piezo type mechanosensitive ion channel component 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 12.4), lung adult (RPKM 5.9) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Piezo2 in Genome Data Viewer
    Location:
    18 E1; 18 35.95 cM
    Exon count:
    56
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (63143284..63520787, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (63010213..63387716, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene adenomatosis polyposis coli down-regulated 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:63137389-63137586 Neighboring gene N-ethylmaleimide sensitive fusion protein attachment protein gamma Neighboring gene STARR-seq mESC enhancer starr_44784 Neighboring gene predicted gene, 36651 Neighboring gene STARR-seq mESC enhancer starr_44785 Neighboring gene STARR-seq mESC enhancer starr_44786 Neighboring gene STARR-seq mESC enhancer starr_44787 Neighboring gene STARR-seq mESC enhancer starr_44788 Neighboring gene predicted gene, 26972 Neighboring gene STARR-seq mESC enhancer starr_44790 Neighboring gene predicted gene, 23581

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Clone Names

    • FLJ23403, MGC182702

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cuticular plate PubMed 
    located_in neuronal cell body membrane PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in stereocilium PubMed 

    General protein information

    Preferred Names
    piezo-type mechanosensitive ion channel component 2
    Names
    family with sequence similarity 38, member B
    family with sequence similarity 38, member B2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039485.5NP_001034574.4  piezo-type mechanosensitive ion channel component 2

      Status: VALIDATED

      Source sequence(s)
      AC124391, AC132378, AC140554, AC162804
      Consensus CDS
      CCDS29296.2
      UniProtKB/Swiss-Prot
      E2JF23, Q8BSM4, Q8CD54, Q9D341
      UniProtKB/TrEMBL
      E9QNW4
      Related
      ENSMUSP00000040019.6, ENSMUST00000047480.13
      Conserved Domains (2) summary
      pfam12166
      Location:24122821
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:13831614
      PIEZO; Piezo

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      63143284..63520787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526169.4XP_006526232.1  piezo-type mechanosensitive ion channel component 2 isoform X4

      UniProtKB/Swiss-Prot
      E2JF23, Q8BSM4, Q8CD54, Q9D341
      Conserved Domains (2) summary
      pfam12166
      Location:24172826
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:13551622
      PIEZO; Piezo
    2. XM_006526168.4XP_006526231.1  piezo-type mechanosensitive ion channel component 2 isoform X3

      UniProtKB/Swiss-Prot
      E2JF23, Q8BSM4, Q8CD54, Q9D341
      Conserved Domains (2) summary
      pfam12166
      Location:24182827
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:13561623
      PIEZO; Piezo
    3. XM_006526173.4XP_006526236.1  piezo-type mechanosensitive ion channel component 2 isoform X7

      UniProtKB/TrEMBL
      A0A494B9V6, S4R2S0
      Related
      ENSMUSP00000138758.3, ENSMUST00000183217.9
      Conserved Domains (2) summary
      pfam12166
      Location:23412750
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:13681602
      PIEZO; Piezo
    4. XM_006526167.4XP_006526230.1  piezo-type mechanosensitive ion channel component 2 isoform X2

      UniProtKB/Swiss-Prot
      E2JF23, Q8BSM4, Q8CD54, Q9D341
      Conserved Domains (2) summary
      pfam12166
      Location:24302839
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:13681635
      PIEZO; Piezo
    5. XM_036161249.1XP_036017142.1  piezo-type mechanosensitive ion channel component 2 isoform X8

      UniProtKB/Swiss-Prot
      E2JF23, Q8BSM4, Q8CD54, Q9D341
      UniProtKB/TrEMBL
      A0A2H4UKA3
      Conserved Domains (2) summary
      pfam12166
      Location:24552864
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:13931660
      PIEZO; Piezo
    6. XM_006526170.4XP_006526233.1  piezo-type mechanosensitive ion channel component 2 isoform X5

      UniProtKB/Swiss-Prot
      E2JF23, Q8BSM4, Q8CD54, Q9D341
      Conserved Domains (2) summary
      pfam12166
      Location:23982807
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:13691603
      PIEZO; Piezo
    7. XM_006526172.4XP_006526235.1  piezo-type mechanosensitive ion channel component 2 isoform X6

      UniProtKB/TrEMBL
      A0A494B9V6
      Conserved Domains (2) summary
      pfam12166
      Location:23752784
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:13691636
      PIEZO; Piezo
    8. XM_006526166.4XP_006526229.1  piezo-type mechanosensitive ion channel component 2 isoform X1

      UniProtKB/Swiss-Prot
      E2JF23, Q8BSM4, Q8CD54, Q9D341
      Conserved Domains (2) summary
      pfam12166
      Location:24312840
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:13691636
      PIEZO; Piezo

    RNA

    1. XR_386006.4 RNA Sequence

    2. XR_001782388.2 RNA Sequence

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