Mir138-2 microRNA 138-2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mir138-2provided by MGI
Official Full Name: microRNA 138-2provided by MGI
Primary source: MGI:MGI:3618733
See related: Ensembl:ENSMUSG00000065512 miRBase:MI0000164; AllianceGenome:MGI:3618733
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mirn138-2; mir-138-2
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 8 C5; 8 46.46 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (95050939..95051009)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (94324311..94324381)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HES1-mediated down-regulation of miR-138 sustains NOTCH1 activation and promotes proliferation and invasion in renal cell carcinoma.
Title: HES1-mediated down-regulation of miR-138 sustains NOTCH1 activation and promotes proliferation and invasion in renal cell carcinoma.
Neuronal miR-138 Represses HSV-2 Lytic Infection by Regulating Viral and Host Genes with Mechanistic Differences from HSV-1.
Title: Neuronal miR-138 Represses HSV-2 Lytic Infection by Regulating Viral and Host Genes with Mechanistic Differences from HSV-1.
Silencing of miR-138-5p sensitizes bone anabolic action to mechanical stimuli.
Title: Silencing of miR-138-5p sensitizes bone anabolic action to mechanical stimuli.
Hyperoside protects cardiomyocytes against hypoxiainduced injury via upregulation of microRNA138.
Title: Hyperoside protects cardiomyocytes against hypoxia‑induced injury via upregulation of microRNA‑138.
miR-138 is an Egr2-dependent microRNA but is dispensable for Schwann cell myelination
Title: Egr2-dependent microRNA-138 is dispensable for peripheral nerve myelination.
miR-138 and ER stress were induced in osteoporosis and then promoted the apoptosis of osteoblasts, at least in part, through TIMP-1.
Title: TIMP-1 suppressed by miR-138 participates in endoplasmic reticulum stress-induced osteoblast apoptosis in osteoporosis.
MiR-138 promoted inflammatory reactions, tissue damage and organ dysfunction, which depends on the direct targeting of SIRT1 by miR-138. Specifically, miR-138 bound to and inhibited the activity of SIRT1 mRNA, followed by the activation of the NFkappaB pathway and the inhibition of the AKT pathway in macrophages, thus promoting inflammation.
Title: MicroRNA-138 Aggravates Inflammatory Responses of Macrophages by Targeting SIRT1 and Regulating the NF-κB and AKT Pathways.
The miR1385p regulate TRIP6 by directly binding the 3'untranslated region of the mRNA and upregulation of TRIP6 rescued the NSC proliferation deficiency induced by miR1385p and abolished miR1385ppromoted neural stem cells differentiation.
Title: MicroRNA‑138‑5p regulates neural stem cell proliferation and differentiation in vitro by targeting TRIP6 expression.
Mechanistically, CREPT regulated beta-catenin/TCF4/cyclin D1 pathway in BC. In conclusion, the data suggested that miR-138/CREPT involved BC progression, providing potential therapeutic targets for BC.
Title: CREPT regulated by miR-138 promotes breast cancer progression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within female sex differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within long-term synaptic potentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within myelination	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.