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    Eras ES cell-expressed Ras [ Mus musculus (house mouse) ]

    Gene ID: 353283, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Erasprovided by MGI
    Official Full Name
    ES cell-expressed Rasprovided by MGI
    Primary source
    MGI:MGI:2665023
    See related
    Ensembl:ENSMUSG00000031160 AllianceGenome:MGI:2665023
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HRAS2; HRasp; ecat5; Ha-Ras2
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. Is expressed in several structures, including blastocyst; early embryo; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human ERAS (ES cell expressed Ras). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 83.1), cerebellum adult (RPKM 64.9) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eras in Genome Data Viewer
    Location:
    X A1.1; X 3.58 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7790515..7794846, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7924276..7928607, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7684 Neighboring gene polyglutamine binding protein 1 Neighboring gene translocase of inner mitochondrial membrane 17b Neighboring gene STARR-seq mESC enhancer starr_46677 Neighboring gene proprotein convertase subtilisin/kexin type 1 inhibitor Neighboring gene histone deacetylase 6 Neighboring gene STARR-seq mESC enhancer starr_46678 Neighboring gene STARR-seq mESC enhancer starr_46679 Neighboring gene predicted gene, 39488 Neighboring gene proteasome (prosome, macropain) subunit, beta type 6, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway. Takahashi K, et al. J Biol Chem, 2005 Sep 23. PMID 16046393
    2. A novel rasH2 mouse carcinogenesis model that is highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis is useful for preclinical chemoprevention studies. Miyamoto S, et al. Carcinogenesis, 2008 Feb. PMID 18174262
    3. The Ras-related gene ERAS is involved in human and murine breast cancer. Suárez-Cabrera C, et al. Sci Rep, 2018 Aug 29. PMID 30158566, Free PMC Article
    4. The roles of ERAS during cell lineage specification of mouse early embryonic development. Zhao ZA, et al. Open Biol, 2015 Aug. PMID 26269429, Free PMC Article
    5. Stimulation of somatic cell reprogramming by ERas-Akt-FoxO1 signaling axis. Yu Y, et al. Stem Cells, 2014 Feb. PMID 23765875

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ERAS may also play important roles in cell lineage specification during mouse early embryonic development.
      Title: The roles of ERAS during cell lineage specification of mouse early embryonic development.
    2. Collectively, these results unravel the significance of the ERas-Akt-FoxO1 signaling axis in iPSC generation, suggesting a possibly shared molecular basis for both somatic reprogramming and cancer initiation
      Title: Stimulation of somatic cell reprogramming by ERas-Akt-FoxO1 signaling axis.
    3. galectin-1 increased DNA synthesis in mouse ES cells via Src, caveolin-1 Akt, and mTOR signaling pathways
      Title: Interaction of galectin-1 with caveolae induces mouse embryonic stem cell proliferation through the Src, ERas, Akt and mTOR signaling pathways.
    4. rasH2 may have a role in susceptibility to chemically-induced tongue and esophageal neoplasms
      Title: A novel rasH2 mouse carcinogenesis model that is highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis is useful for preclinical chemoprevention studies.
    5. ERas and Rheb are two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway; ERas is localized at the plasma membrane, while Rheb is on endomembranes.
      Title: Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway.
    6. transforming oncogene ERas is important in the tumour-like growth properties of embryonic stem cells
      Title: Role of ERas in promoting tumour-like properties in mouse embryonic stem cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GTPase ERas
    Names
    E-Ras
    embryonic stem cell-expressed Ras
    small GTPase E-Ras
    NP_853526.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181548.2 → NP_853526.1  GTPase ERas

      See identical proteins and their annotated locations for NP_853526.1

      Status: PROVISIONAL

      Source sequence(s)
      AB093573
      Consensus CDS
      CCDS29980.1
      UniProtKB/Swiss-Prot
      Q7TN89
      UniProtKB/TrEMBL
      Q0VEC9
      Related
      ENSMUSP00000033500.5, ENSMUST00000033500.5
      Conserved Domains (2) summary
      smart00010
      Location:40 → 201
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cl21455
      Location:42 → 201
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      7790515..7794846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TN89.1 GenPept UniProtKB/Swiss-Prot:Q7TN89

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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