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    RHOA ras homolog family member A [ Sus scrofa (pig) ]

    Gene ID: 396849, updated on 3-Dec-2024

    Summary

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    Official Symbol
    RHOAprovided by VGNC
    Official Full Name
    ras homolog family member Aprovided by VGNC
    Primary source
    VGNC:VGNC:92284
    See related
    Ensembl:ENSSSCG00000022080
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Ubiquitous expression in lung (RPKM 182.1), spleen (RPKM 174.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See RHOA in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 13 NC_010455.5 (31918484..31991207, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 13 NC_010455.4 (35149494..35160516, complement)

    Chromosome 13 - NC_010455.5Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 4 Neighboring gene uncharacterized LOC110256230 Neighboring gene glutathione peroxidase 1 Neighboring gene T cell leukemia translocation altered Neighboring gene aminomethyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. RhoA suppresses pseudorabies virus replication in vitro. Li XM, et al. Virol J, 2023 Nov 15. PMID 37968757, Free PMC Article
    2. Thromboxane-induced actin polymerization in hypoxic pulmonary artery is independent of Rho. Fediuk J, et al. Am J Physiol Lung Cell Mol Physiol, 2012 Jan 1. PMID 21926266
    3. Expression of RhoA mRNA and activated RhoA in urothelium and smooth muscle, and effects of a Rho-kinase inhibitor on contraction of the porcine urinary bladder. Nakanishi K, et al. Neurourol Urodyn, 2009. PMID 19214992
    4. Pseudorabies virus US3 triggers RhoA phosphorylation to reorganize the actin cytoskeleton. Jacob T, et al. J Gen Virol, 2015 Aug. PMID 25883194
    5. Rac1 and RhoA as regulators of endothelial phenotype and barrier function in hypoxia-induced neonatal pulmonary hypertension. Wojciak-Stothard B, et al. Am J Physiol Lung Cell Mol Physiol, 2006 Jun. PMID 16428270

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RhoA suppresses pseudorabies virus replication in vitro.
      Title: RhoA suppresses pseudorabies virus replication in vitro.
    2. Pseudorabies virus US3 expression led to RhoA phosphorylation at serine 188 to induce actin rearrangements.
      Title: Pseudorabies virus US3 triggers RhoA phosphorylation to reorganize the actin cytoskeleton.
    3. Data indicate that TNF-alpha stimulates Rac, ADAM17/TACE, and RhoA through the guanine nucleotide exchange factor (GEF)-H1.
      Title: Central role of the exchange factor GEF-H1 in TNF-α-induced sequential activation of Rac, ADAM17/TACE, and RhoA in tubular epithelial cells.
    4. Contractile pulmonary arterial myocytes exhibit marked Rho-dependent actin polymerization in hypoxia, with increased active RhoA and LIMK phosphorylation.
      Title: Thromboxane-induced actin polymerization in hypoxic pulmonary artery is independent of Rho.
    5. Results suggest that Rac1 and RhoA are regulated by TGFbeta1 in the process of endothelial tube formation in collagen I gels.
      Title: TGFbeta1-induced aortic endothelial morphogenesis requires signaling by small GTPases Rac1 and RhoA.
    6. Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin.
      Title: Thrombin stimulates smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin.
    7. The concentration of RhoA mRNA and activated RhoA enzyme were greater in urothelium than in detrusor. Rho kinase inhibitor Y-27632 showed a stronger inhibitory effect in detrusor with intact urothelium.
      Title: Expression of RhoA mRNA and activated RhoA in urothelium and smooth muscle, and effects of a Rho-kinase inhibitor on contraction of the porcine urinary bladder.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transforming protein RhoA
    Names
    Rho A
    ras homolog gene family, member A
    NP_001231366.1
    XP_020924180.1
    XP_020924181.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001244437.1 → NP_001231366.1  transforming protein RhoA

      Status: VALIDATED

      Source sequence(s)
      AK231928, DB807234, EH007776, EV970410, EW113459
      UniProtKB/TrEMBL
      A0A4X1ST20, A0A8D0TKE0, A0A8W4FKM4, I3LVS7
      Related
      ENSSSCP00000045785.1, ENSSSCT00000062870.3
      Conserved Domains (1) summary
      cd01870
      Location:5 → 179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010455.5 Reference Sscrofa11.1 Primary Assembly

      Range
      31918484..31991207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021068521.1 → XP_020924180.1  transforming protein RhoA isoform X1

      UniProtKB/TrEMBL
      A0A4X1ST20, A0A8D0TKE0, A0A8W4FKM4, I3LVS7
      Conserved Domains (1) summary
      cd01870
      Location:5 → 179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

    2. XM_021068522.1 → XP_020924181.1  transforming protein RhoA isoform X1

      UniProtKB/TrEMBL
      A0A4X1ST20, A0A8D0TKE0, A0A8W4FKM4, I3LVS7
      Conserved Domains (1) summary
      cd01870
      Location:5 → 179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
    Nucleotide Protein Strain
    Heading Accession and Version

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