Fmo3 flavin containing dimethylaniline monoxygenase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fmo3provided by RGD
Official Full Name: flavin containing dimethylaniline monoxygenase 3provided by RGD
Primary source: RGD:619761
See related: EnsemblRapid:ENSRNOG00000003620 AllianceGenome:RGD:619761
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables N,N-dimethylaniline monooxygenase activity; NADP binding activity; and amino acid binding activity. Involved in xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hypertension; inherited metabolic disorder; and trimethylaminuria. Orthologous to human FMO3 (flavin containing dimethylaniline monoxygenase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 845.6), Liver (RPKM 691.8) and 3 other tissues See more
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Genomic context

Location:: 13q22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (77838899..77868869, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (75309367..75334915, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (80837418..80856214, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show a compelling visual demonstration of the isoform-specific localization patterns of FMO1, -3, and -4 in the rat liver and kidney and the first evidence for expression of FMO4 at the protein level in mouse and human liver and kidney microsomes.
Title: Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes.
Results demonstrate many similar properties between rat hepatic and renal FMO3 forms and suggest that renal FMO3 may play an important role in kidney metabolism of xenobiotics containing sulfur and selenium atoms.
Title: Purification and characterization of flavin-containing monooxygenase isoform 3 from rat kidney microsomes.
the relationship between gender and development in the expression of FMO3 in the liver and kidney was determined
Title: Physiological factors affecting the expression of FMO1 and FMO3 in the rat liver and kidney.

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General gene information

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Markers

BI283117 (e-PCR)
- UniSTS:243479

AI169813 (e-PCR)
- UniSTS:250422

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N,N-dimethylaniline monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N,N-dimethylaniline monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables N,N-dimethylaniline monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables NADP binding	IPI Inferred from Physical Interaction more info	PubMed
enables albendazole monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables amino acid binding	IPI Inferred from Physical Interaction more info	PubMed
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables hypotaurine monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables hypotaurine monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables monooxygenase activity	TAS Traceable Author Statement more info	PubMed
enables trimethylamine monooxygenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in taurine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in taurine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: flavin-containing monooxygenase 3

Names: FMO 3; dimethylaniline monooxygenase [N-oxide-forming] 3; dimethylaniline oxidase 3; flavin containing monooxygenase 3; hepatic flavin-containing monooxygenase 3; trimethylamine monooxygenase

NP_445885.2

EC 1.14.13.148

EC 1.14.13.32

EC 1.14.13.8

XP_038947055.1

EC 1.14.13.148

EC 1.14.13.32

EC 1.14.13.8

XP_038947056.1

EC 1.14.13.148

EC 1.14.13.32

EC 1.14.13.8

XP_063128721.1

EC 1.14.13.148

EC 1.14.13.32

EC 1.14.13.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053433.2 → NP_445885.2 flavin-containing monooxygenase 3

See identical proteins and their annotated locations for NP_445885.2

Status: PROVISIONAL

Source sequence(s)

BC087008

UniProtKB/Swiss-Prot

Q5PQV6, Q9EQ76

UniProtKB/TrEMBL

A0A0G2JSI0, A6IDB5

Related

ENSRNOP00000004864.4, ENSRNOT00000004864.7

Conserved Domains (1) summary

pfam00743
Location:2 → 530

FMO-like; Flavin-binding monooxygenase-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

77838899..77868869 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272651.1 → XP_063128721.1 flavin-containing monooxygenase 3 isoform X1

UniProtKB/Swiss-Prot

Q5PQV6, Q9EQ76

UniProtKB/TrEMBL

A0A0G2JSI0, A6IDB5
XM_039091127.2 → XP_038947055.1 flavin-containing monooxygenase 3 isoform X1

UniProtKB/Swiss-Prot

Q5PQV6, Q9EQ76

UniProtKB/TrEMBL

A0A0G2JSI0, A6IDB5

Conserved Domains (1) summary

pfam00743
Location:2 → 530

FMO-like; Flavin-binding monooxygenase-like
XM_039091128.2 → XP_038947056.1 flavin-containing monooxygenase 3 isoform X1

UniProtKB/Swiss-Prot

Q5PQV6, Q9EQ76

UniProtKB/TrEMBL

A0A0G2JSI0, A6IDB5

Conserved Domains (1) summary

pfam00743
Location:2 → 530

FMO-like; Flavin-binding monooxygenase-like