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    Cript CXXC repeat containing interactor of PDZ3 domain [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56725, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Criptprovided by RGD
    Official Full Name
    CXXC repeat containing interactor of PDZ3 domainprovided by RGD
    Primary source
    RGD:621545
    See related
    EnsemblRapid:ENSRNOG00000015215 AllianceGenome:RGD:621545
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables PDZ domain binding activity and microtubule binding activity. Involved in cytoplasmic microtubule organization; protein localization to microtubule; and regulation of postsynaptic density organization. Located in dendritic shaft; dendritic spine; and neuronal cell body. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in Rothmund-Thomson syndrome. Orthologous to human CRIPT (CXXC repeat containing interactor of PDZ3 domain). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 205.2), Brain (RPKM 168.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cript in Genome Data Viewer
    Location:
    6q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (13334978..13342934, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (7581428..7589384, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (10594147..10602103)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479310 Neighboring gene karyopherin subunit alpha 2 like 1 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class F Neighboring gene ras homolog family member Q Neighboring gene large ribosomal subunit protein eL8-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Laminar organization of the NMDA receptor complex within the postsynaptic density. Valtschanoff JG, et al. J Neurosci, 2001 Feb 15. PMID 11160391, Free PMC Article
    2. Interaction Between CRIPT and PSD-95 Is Required for Proper Dendritic Arborization in Hippocampal Neurons. Omelchenko A, et al. Mol Neurobiol, 2020 May. PMID 32157575, Free PMC Article
    3. Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95. Passafaro M, et al. Nat Neurosci, 1999 Dec. PMID 10570482
    4. A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95. Saro D, et al. Biochemistry, 2007 May 29. PMID 17474715, Free PMC Article
    5. CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90. Niethammer M, et al. Neuron, 1998 Apr. PMID 9581762

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interaction Between CRIPT and PSD-95 Is Required for Proper Dendritic Arborization in Hippocampal Neurons.
      Title: Interaction Between CRIPT and PSD-95 Is Required for Proper Dendritic Arborization in Hippocampal Neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PDZ domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic microtubule organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to microtubule IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynaptic density assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic density assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynaptic density protein 95 clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendritic shaft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density, intracellular component IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cysteine-rich PDZ-binding protein
    Names
    cysteine-rich interactor of PDZ three
    cysteine-rich interactor of PDZ3
    postsynaptic protein Cript

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019907.1 → NP_063972.1  cysteine-rich PDZ-binding protein

      Status: PROVISIONAL

      Source sequence(s)
      AF047384
      UniProtKB/Swiss-Prot
      Q792Q4
      UniProtKB/TrEMBL
      A0A8I6AVC2, A6H9E9
      Related
      ENSRNOP00000097693.1, ENSRNOT00000113445.2
      Conserved Domains (1) summary
      pfam10235
      Location:11 → 99
      Cript; Microtubule-associated protein CRIPT

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      13334978..13342934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q792Q4.1 GenPept UniProtKB/Swiss-Prot:Q792Q4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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