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    Cntn2 contactin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25356, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cntn2provided by RGD
    Official Full Name
    contactin 2provided by RGD
    Primary source
    RGD:3821
    See related
    EnsemblRapid:ENSRNOG00000009033 AllianceGenome:RGD:3821
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tax; TAG1; TAG-1; TAG-564
    Summary
    Predicted to enable carbohydrate binding activity and cell-cell adhesion mediator activity. Involved in axonogenesis and cell-matrix adhesion. Located in plasma membrane and synapse. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 5. Orthologous to human CNTN2 (contactin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 99.6), Lung (RPKM 11.0) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cntn2 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (46497269..46528112, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (43942868..43975973, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (49280913..49314061, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene dual serine/threonine and tyrosine protein kinase Neighboring gene RB binding protein 5, histone lysine methyltransferase complex subunit Neighboring gene U6 spliceosomal RNA Neighboring gene transmembrane protein 81 Neighboring gene neurofascin Neighboring gene transmembrane protein 126A, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cell adhesion mediator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cell adhesion mediator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled adenosine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of G protein-coupled adenosine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adult walking behavior IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within adult walking behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axonal fasciculation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within axonal fasciculation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axonogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-matrix adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in central nervous system myelination IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within central nervous system myelination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cerebral cortex GABAergic interneuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cerebral cortex GABAergic interneuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in clustering of voltage-gated potassium channels IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in clustering of voltage-gated potassium channels ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of localization in cell IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of protein localization to juxtaparanode region of axon IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of protein localization to juxtaparanode region of axon ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in learning IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within learning ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of adenosine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of adenosine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein processing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in presynaptic membrane organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in presynaptic membrane organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in presynaptic membrane organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within protein localization to juxtaparanode region of axon ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to juxtaparanode region of axon ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in reduction of food intake in response to dietary excess IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in reduction of food intake in response to dietary excess ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of astrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of astrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of axon diameter IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of axon diameter ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuronal synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to dietary excess ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon initial segment IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in axon initial segment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in juxtaparanode region of axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in juxtaparanode region of axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    located_in myelin sheath ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in node of Ranvier IEA
    Inferred from Electronic Annotation
    more info
     
    located_in node of Ranvier ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    contactin-2
    Names
    TAX-1
    axonal glycoprotein TAG-1
    axonin-1
    contactin 2 (axonal)
    transient axonal glycoprotein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012884.2NP_037016.2  contactin-2 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      P22063
      UniProtKB/TrEMBL
      A6IC54, G3V758
      Related
      ENSRNOP00000012190.2, ENSRNOT00000012190.5
      Conserved Domains (6) summary
      cd05728
      Location:330414
      Ig4_Contactin-2-like; Fourth Ig domain of the neural cell adhesion molecule contactin-2, and similar domains
      cd00063
      Location:817909
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:509515
      Ig; Ig strand A [structural motif]
      cd04969
      Location:419507
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cd05727
      Location:141230
      Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2, and similar domains
      cl11960
      Location:509605
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      46497269..46528112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090383.2XP_038946311.1  contactin-2 isoform X2

      UniProtKB/Swiss-Prot
      P22063
      Conserved Domains (6) summary
      cd05728
      Location:330414
      Ig4_Contactin-2-like; Fourth Ig domain of the neural cell adhesion molecule contactin-2, and similar domains
      cd00063
      Location:816908
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:509515
      Ig; Ig strand A [structural motif]
      cd04969
      Location:419507
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cd05727
      Location:141230
      Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2, and similar domains
      cl11960
      Location:509604
      Ig; Immunoglobulin domain
    2. XM_006249746.5XP_006249808.1  contactin-2 isoform X1

      See identical proteins and their annotated locations for XP_006249808.1

      UniProtKB/Swiss-Prot
      P22063
      UniProtKB/TrEMBL
      A6IC54, G3V758
      Conserved Domains (6) summary
      cd05728
      Location:330414
      Ig4_Contactin-2-like; Fourth Ig domain of the neural cell adhesion molecule contactin-2, and similar domains
      cd00063
      Location:817909
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:509515
      Ig; Ig strand A [structural motif]
      cd04969
      Location:419507
      Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin
      cd05727
      Location:141230
      Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2, and similar domains
      cl11960
      Location:509605
      Ig; Immunoglobulin domain

    RNA

    1. XR_010056901.1 RNA Sequence