Kcnh5 potassium voltage-gated channel subfamily H member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnh5provided by RGD
Official Full Name: potassium voltage-gated channel subfamily H member 5provided by RGD
Primary source: RGD:621417
See related: EnsemblRapid:ENSRNOG00000009542 AllianceGenome:RGD:621417
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Eag2
Summary: Enables delayed rectifier potassium channel activity and transmembrane transporter binding activity. Involved in potassium ion transport. Predicted to be located in cell surface. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human KCNH5 (potassium voltage-gated channel subfamily H member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 96.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (99350947..99643856, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (93615174..93908107, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (97872831..98157087, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KCNH5 deletion increases autism susceptibility by regulating neuronal growth through Akt/mTOR signaling pathway.
Title: KCNH5 deletion increases autism susceptibility by regulating neuronal growth through Akt/mTOR signaling pathway.
Our findings suggest that Eag1 and Eag2 K+ channels may modulate membrane excitability in both the dendrosomatic and the axonal compartments and that Eag1 may additionally regulate neurotransmitter release and postsynaptic signaling
Title: The punctate localization of rat Eag1 K+ channels is conferred by the proximal post-CNBHD region.
Isolation rearing changes the expression of Eag2 potassium channel in the midbrain, striatum, cortex, hippocampus and olfactory bult; and reduces exploratory activity in the center of an open field.
Title: Eag 1, Eag 2 and Kcnn3 gene brain expression of isolated reared rats.
Compared to rEag2, rEag1 expression encompasses a significantly broader range of the somatodendritic compartment of the retinal ganglion cell.
Title: Differential localization of rat Eag1 and Eag2 potassium channels in the retina.
Immunofluorescence studies using markers for different compartments of neurons demonstrated a differential expression pattern of rEag1 and rEag2 K channels in the somatodendritic region.
Title: Differential localization of rat Eag1 and Eag2 K+ channels in hippocampal neurons.

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General gene information

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Markers

d6arb20 (e-PCR)
- UniSTS:122179

D6Mit8 (e-PCR), detects polymorphism
- UniSTS:119390

Kcnh5 (e-PCR), detects polymorphism
- UniSTS:496048

31.MMHAP7FLC4.seq (e-PCR)
- UniSTS:186304

WI-15244 (e-PCR)
- UniSTS:64509

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables delayed rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables delayed rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: voltage-gated delayed rectifier potassium channel KCNH5; potassium voltage-gated channel subfamily H member 5

Names: ether-a-go-go potassium channel 2; potassium channel, voltage gated eag related subfamily H, member 5; potassium voltage-gated channel, subfamily H (eag-related), member 5; rEAG2; voltage-gated potassium channel subunit Kv10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133610.2 → NP_598294.1 voltage-gated delayed rectifier potassium channel KCNH5

See identical proteins and their annotated locations for NP_598294.1

Status: PROVISIONAL

Source sequence(s)

AJ250280

UniProtKB/Swiss-Prot

O88893, Q9EPI9, Q9QXT2

Related

ENSRNOP00000013275.2, ENSRNOT00000013275.6

Conserved Domains (3) summary

PLN03192
Location:217 → 616

PLN03192; Voltage-dependent potassium channel; Provisional

COG0664
Location:544 → 723

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

pfam13426
Location:39 → 132

PAS_9; PAS domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

99350947..99643856 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111744.2 → XP_038967672.1 potassium voltage-gated channel subfamily H member 5 isoform X1

UniProtKB/TrEMBL

A6HC74

Conserved Domains (2) summary

PLN03192
Location:14 → 310

PLN03192; Voltage-dependent potassium channel; Provisional

cd00038
Location:244 → 354

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...