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    Gadd45g growth arrest and DNA-damage-inducible, gamma [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291005, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gadd45gprovided by RGD
    Official Full Name
    growth arrest and DNA-damage-inducible, gammaprovided by RGD
    Primary source
    RGD:1311796
    See related
    EnsemblRapid:ENSRNOG00000013090 AllianceGenome:RGD:1311796
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including positive regulation of MAPK cascade; positive regulation of apoptotic process; and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within negative regulation of protein kinase activity and positive regulation of MAPK cascade. Predicted to be active in cytoplasm and nucleus. Biomarker of mesangial proliferative glomerulonephritis. Orthologous to human GADD45G (growth arrest and DNA damage inducible gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 128.0), Heart (RPKM 101.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gadd45g in Genome Data Viewer
    Location:
    17p14
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (13528606..13530351, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (13376842..13378587, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (13391474..13393219, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482768 Neighboring gene uncharacterized LOC120097809 Neighboring gene semaphorin 4D Neighboring gene uncharacterized LOC134482683 Neighboring gene SECIS binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Apoptosis of glomerular mesangial cells induced by sublytic C5b-9 complexes in rats with Thy-1 nephritis is dependent on Gadd45 gamma upregulation. Qiu W, et al. Eur J Immunol, 2009 Nov. PMID 19882653
    2. Molecular cloning of rat GADD45gamma, gene induction and its role during neuronal cell death. Kojima S, et al. FEBS Lett, 1999 Mar 12. PMID 10100865
    3. The crystal structure and dimerization interface of GADD45gamma. Schrag JD, et al. Proc Natl Acad Sci U S A, 2008 May 6. PMID 18445651, Free PMC Article
    4. Gene expression profile and overexpression of apoptosis-related genes (NGFI-B and Gadd 45 gamma) in early phase of Thy-1 nephritis model. Xu JH, et al. Cell Tissue Res, 2006 Oct. PMID 16736195
    5. Sex differences in Gadd45b expression and methylation in the developing rodent amygdala. Kigar SL, et al. Brain Res, 2016 Jul 1. PMID 27086974, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MicroRNA-128-1-5p attenuates myocardial ischemia/reperfusion injury by suppressing Gadd45g-mediated apoptotic signaling.
      Title: MicroRNA-128-1-5p attenuates myocardial ischemia/reperfusion injury by suppressing Gadd45g-mediated apoptotic signaling.
    2. Report of sex differences in the expression of growth arrest and DNA damage inducible factor beta (Gadd45b), but not family members alpha (a) or gamma (g), in the neonatal and juvenile rodent amygdala
      Title: Sex differences in Gadd45b expression and methylation in the developing rodent amygdala.
    3. Gadd45 gamma gene expression is involved in regulating glomerular mesangial cell apoptosis mediated by sublytic C5b-9 in Thy-1 nephritis
      Title: Apoptosis of glomerular mesangial cells induced by sublytic C5b-9 complexes in rats with Thy-1 nephritis is dependent on Gadd45 gamma upregulation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    growth arrest and DNA damage-inducible protein GADD45 gamma
    Names
    GADD45gamma
    growth arrest and DNA damage inducible
    growth arrest and DNA-damage-inducible 45 gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077640.2 → NP_001071108.1  growth arrest and DNA damage-inducible protein GADD45 gamma

      See identical proteins and their annotated locations for NP_001071108.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      Q9WTQ7
      UniProtKB/TrEMBL
      B5DEF0
      Related
      ENSRNOP00000018251.4, ENSRNOT00000018252.9
      Conserved Domains (1) summary
      pfam01248
      Location:24 → 106
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      13528606..13530351 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WTQ7.1 GenPept UniProtKB/Swiss-Prot:Q9WTQ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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