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    Tmco3 transmembrane and coiled-coil domains 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306607, updated on 27-Nov-2024

    Summary

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    Symbol
    Tmco3provided by RGD
    Full Name
    transmembrane and coiled-coil domains 3provided by RGD
    Primary source
    RGD:1306586
    See related
    EnsemblRapid:ENSRNOG00000046973 AllianceGenome:RGD:1306586
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306586
    Summary
    Predicted to enable potassium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; proton transmembrane transport; and sodium ion transport. Predicted to be located in membrane. Orthologous to human TMCO3 (transmembrane and coiled-coil domains 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 77.9), Heart (RPKM 76.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmco3 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (82919324..82956485, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (76217146..76254309, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (81035001..81072145)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene transcription factor Dp-1 Neighboring gene uncharacterized LOC102548465 Neighboring gene defective in cullin neddylation 1 domain containing 2 Neighboring gene ADP-ribosylhydrolase like 1 Neighboring gene uncharacterized LOC102548530

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables potassium:proton antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane and coiled-coil domain-containing protein 3
    Names
    transmembrane and coiled-coil domain-containing protein 3-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135857.1 → NP_001129329.1  transmembrane and coiled-coil domain-containing protein 3 isoform 1 precursor

      Status: PROVISIONAL

      Source sequence(s)
      CH473970
      UniProtKB/TrEMBL
      A6IWH9
      Related
      ENSRNOP00000105364.1, ENSRNOT00000164504.1
      Conserved Domains (2) summary
      COG1196
      Location:43 → 202
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00999
      Location:274 → 646
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    2. NM_001415083.1 → NP_001402012.1  transmembrane and coiled-coil domain-containing protein 3 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      D4A9M9
      Related
      ENSRNOP00000075815.1, ENSRNOT00000092470.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      82919324..82956485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275467.1 → XP_063131537.1  transmembrane and coiled-coil domain-containing protein 3 isoform X2

    2. XM_017600159.3 → XP_017455648.1  transmembrane and coiled-coil domain-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      A6IWH9
      Conserved Domains (2) summary
      COG1196
      Location:43 → 202
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00999
      Location:274 → 646
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    3. XM_017600154.3 → XP_017455643.1  transmembrane and coiled-coil domain-containing protein 3 isoform X1

      Conserved Domains (2) summary
      pfam00999
      Location:274 → 564
      Na_H_Exchanger; Sodium/hydrogen exchanger family
      pfam01519
      Location:88 → 195
      DUF16; Protein of unknown function DUF16

    4. XM_063275474.1 → XP_063131544.1  transmembrane and coiled-coil domain-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      D4A9M9

    5. XM_039094592.2 → XP_038950520.1  transmembrane and coiled-coil domain-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      A6IWH9
      Conserved Domains (2) summary
      COG1196
      Location:43 → 202
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00999
      Location:274 → 646
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    6. XM_063275473.1 → XP_063131543.1  transmembrane and coiled-coil domain-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      D4A9M9

    7. XM_063275469.1 → XP_063131539.1  transmembrane and coiled-coil domain-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      A6IWH9

    8. XM_063275466.1 → XP_063131536.1  transmembrane and coiled-coil domain-containing protein 3 isoform X1

    9. XM_063275471.1 → XP_063131541.1  transmembrane and coiled-coil domain-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      D4A9M9

    10. XM_063275468.1 → XP_063131538.1  transmembrane and coiled-coil domain-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      A6IWH9

    11. XM_063275475.1 → XP_063131545.1  transmembrane and coiled-coil domain-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      D4A9M9

    12. XM_063275470.1 → XP_063131540.1  transmembrane and coiled-coil domain-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      A6IWH9

    13. XM_063275472.1 → XP_063131542.1  transmembrane and coiled-coil domain-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      D4A9M9

    14. XM_039094594.2 → XP_038950522.1  transmembrane and coiled-coil domain-containing protein 3 isoform X6

      Conserved Domains (2) summary
      COG1196
      Location:43 → 202
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl01133
      Location:274 → 408
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    15. XM_039094593.2 → XP_038950521.1  transmembrane and coiled-coil domain-containing protein 3 isoform X5

      Conserved Domains (2) summary
      COG1196
      Location:43 → 202
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl01133
      Location:274 → 408
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    RNA

    1. XR_005494627.2 RNA Sequence

    2. XR_005494625.2 RNA Sequence

    3. XR_005494626.2 RNA Sequence

    4. XR_005494629.2 RNA Sequence

    5. XR_005494630.2 RNA Sequence

    6. XR_005494628.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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