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    Sbno2 strawberry notch homolog 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314619, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sbno2provided by RGD
    Official Full Name
    strawberry notch homolog 2provided by RGD
    Primary source
    RGD:1307194
    See related
    EnsemblRapid:ENSRNOG00000013987 AllianceGenome:RGD:1307194
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Stno; RGD1307194
    Summary
    Predicted to enable chromatin DNA binding activity and histone binding activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; macrophage activation involved in immune response; and regulation of DNA-templated transcription. Predicted to act upstream of or within bone mineralization; bone trabecula morphogenesis; and osteoclast fusion. Predicted to be active in nucleus. Orthologous to human SBNO2 (strawberry notch homolog 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 54.0), Adrenal (RPKM 51.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sbno2 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10256221..10300175)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9605572..9649529)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12471805..12515700)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene CACN subunit beta associated regulatory protein Neighboring gene serine/threonine kinase 11 Neighboring gene uncharacterized LOC134479811 Neighboring gene uncharacterized LOC134479812 Neighboring gene glutathione peroxidase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous system. Grill M, et al. Glia, 2015 Oct. PMID 25903009, Free PMC Article
    2. Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway. El Kasmi KC, et al. J Immunol, 2007 Dec 1. PMID 18025162
    3. Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. Maruyama K, et al. J Exp Med, 2013 Sep 23. PMID 23980096, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within bone trabecula morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interleukin-11 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interleukin-6 IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to interleukin-6 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in macrophage activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in macrophage activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multinuclear osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in osteoclast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within osteoclast fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein strawberry notch homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108068.1 → NP_001101538.1  protein strawberry notch homolog 2

      See identical proteins and their annotated locations for NP_001101538.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474029
      UniProtKB/TrEMBL
      A0A8I6A186, A6K8R8, A6K8R9, D3ZDU8
      Related
      ENSRNOP00000062533.2, ENSRNOT00000068197.5
      Conserved Domains (2) summary
      pfam13871
      Location:659 → 937
      Helicase_C_4; C-terminal domain on Strawberry notch homologue
      pfam13872
      Location:145 → 433
      AAA_34; P-loop containing NTP hydrolase pore-1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10256221..10300175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594814.3 → XP_017450303.1  protein strawberry notch homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JZZ8, A0A8I6A186, A6K8R6, A6K8R9
      Related
      ENSRNOP00000071247.1, ENSRNOT00000077146.3
      Conserved Domains (2) summary
      pfam13871
      Location:726 → 1004
      Helicase_C_4; C-terminal domain on Strawberry notch homologue
      pfam13872
      Location:212 → 500
      AAA_34; P-loop containing NTP hydrolase pore-1

    2. XM_006240908.5 → XP_006240970.1  protein strawberry notch homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_006240970.1

      UniProtKB/TrEMBL
      A0A0G2JZZ8, A0A8I6A186, A6K8R6, A6K8R9
      Conserved Domains (2) summary
      pfam13871
      Location:726 → 1004
      Helicase_C_4; C-terminal domain on Strawberry notch homologue
      pfam13872
      Location:212 → 500
      AAA_34; P-loop containing NTP hydrolase pore-1

    3. XM_008765095.4 → XP_008763317.1  protein strawberry notch homolog 2 isoform X2

      See identical proteins and their annotated locations for XP_008763317.1

      UniProtKB/TrEMBL
      A0A8I6A186, A6K8R8, A6K8R9, D3ZDU8
      Related
      ENSRNOP00000084971.1, ENSRNOT00000099606.2
      Conserved Domains (2) summary
      pfam13871
      Location:659 → 937
      Helicase_C_4; C-terminal domain on Strawberry notch homologue
      pfam13872
      Location:145 → 433
      AAA_34; P-loop containing NTP hydrolase pore-1
    Nucleotide Protein Strain
    Heading Accession and Version

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