Ccn3 cellular communication network factor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ccn3provided by RGD
Official Full Name: cellular communication network factor 3provided by RGD
Primary source: RGD:621553
See related: AllianceGenome:RGD:621553
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nov
Summary: Predicted to enable heparin binding activity and signaling receptor binding activity. Involved in chondrocyte differentiation and negative regulation of sensory perception of pain. Acts upstream of or within regulation of gene expression. Located in several cellular components, including dendrite; gap junction; and neuronal cell body. Orthologous to human CCN3 (cellular communication network factor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 249.2), Heart (RPKM 225.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q32

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (87983788..87990810)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (86094000..86101022)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (94375134..94382154)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study aimed to investigate the role of TNC and CCN3 as prognostic factors for post hepatectomy liver failure (PHLF) in a rat model of partial hepatectomy and 50 patients following partial hepatectomy.
Title: The Predictive Role of Tenascin-C and Cellular Communication Network Factor 3 (CCN3) in Post Hepatectomy Liver Failure in a Rat Model and 50 Patients Following Partial Hepatectomy.
These results suggest that CCN3 is a secreted protein of the ductus arteriosus (DA) smooth muscle cells induced by PGE2 to suppress intimal cushion formation of the DA.
Title: CCN3 secreted by prostaglandin E(2) inhibits intimal cushion formation in the rat ductus arteriosus.
CCN3 is expressed by articular chondrocytes in normal rat knees, whereas it is rapidly down-regulated in osteoarthritic knees.
Title: Novel role of CCN3 that maintains the differentiated phenotype of articular cartilage.
CCN3 can promote dentinogenesis by coordinating proliferation and odontoblastic differentiation of dental pulp stem cells via modulating Notch and BMP2 signaling pathways.
Title: Promotion of dentin regeneration via CCN3 modulation on Notch and BMP signaling pathways.
A novel, dual role of CCN3 in experimental glomerulonephritis: pro-angiogenic and antimesangioproliferative effects.
Title: A novel, dual role of CCN3 in experimental glomerulonephritis: pro-angiogenic and antimesangioproliferative effects.
Prenatal lead exposure decreased the NOV protein and mRNA expression in the hippocampus of offspring.
Title: [Effects of prenatal exposure to lead on hippocampal nephroblastoma over-expressed gene expression of offspring].
Data show that CCN family protein 3 (CCN3) is abundantly produced in rat developing epiphyseal cartilage.
Title: Novel effects of CCN3 that may direct the differentiation of chondrocytes.
Recombinant expression, purification, and functional characterisation of connective tissue growth factor and nephroblastoma-overexpressed protein
Title: Recombinant expression, purification, and functional characterisation of connective tissue growth factor and nephroblastoma-overexpressed protein.
These findings identify a new paracrine role of NOV in the development of cerebellar granule neurons.
Title: NOV/CCN3 promotes maturation of cerebellar granule neuron precursors.
CCN3 suppresses neointimal thickening through the inhibition of vascular smooth cell migration and proliferation.
Title: CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

Nov (e-PCR), detects polymorphism
- UniSTS:526865

RH139893 (e-PCR)
- UniSTS:221977

Nov (e-PCR), detects polymorphism
- UniSTS:508569

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Notch binding	ISO Inferred from Sequence Orthology more info
enables growth factor activity	TAS Traceable Author Statement more info	PubMed
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	ISO Inferred from Sequence Orthology more info
enables hormone activity	ISS Inferred from Sequence or Structural Similarity more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in bone regeneration	ISO Inferred from Sequence Orthology more info
involved_in bone regeneration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion mediated by integrin	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in chondrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in endothelial cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in endothelial cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in fibroblast migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in hematopoietic stem cell homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect negative regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect negative regulation of SMAD protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chondrocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monocyte chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of myotube differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myotube differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ossification	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in type B pancreatic cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in type B pancreatic cell proliferation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in gap junction	IDA Inferred from Direct Assay more info	PubMed
located_in gap junction	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CCN family member 3

Names: nephroblastoma overexpressed; nephroblastoma-overexpressed gene protein homolog; novH; protein NOV homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030868.2 → NP_110495.1 CCN family member 3 precursor

See identical proteins and their annotated locations for NP_110495.1

Status: PROVISIONAL

Source sequence(s)

BC072548

UniProtKB/Swiss-Prot

Q9QZQ5

UniProtKB/TrEMBL

A6HRG0

Conserved Domains (3) summary

smart00121
Location:28 → 97

IB; Insulin growth factor-binding protein homologues

smart00041
Location:263 → 332

CT; C-terminal cystine knot-like domain (CTCK)

smart00214
Location:104 → 164

VWC; von Willebrand factor (vWF) type C domain