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    Hectd1 HECT domain E3 ubiquitin protein ligase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362736, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hectd1provided by RGD
    Official Full Name
    HECT domain E3 ubiquitin protein ligase 1provided by RGD
    Primary source
    RGD:1561653
    See related
    EnsemblRapid:ENSRNOG00000006905 AllianceGenome:RGD:1561653
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561653
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Predicted to act upstream of or within several processes, including chordate embryonic development; circulatory system development; and protein ubiquitination. Predicted to be active in nuclear speck. Orthologous to human HECTD1 (HECT domain E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 596.9), Heart (RPKM 507.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hectd1 in Genome Data Viewer
    Location:
    6q23
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (74916803..75003408, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (69181429..69268045, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (72509658..72596285, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene cochlin Neighboring gene striatin 3 Neighboring gene adaptor related protein complex 4 subunit sigma 1 Neighboring gene uncharacterized LOC120103536 Neighboring gene uncharacterized LOC134479181 Neighboring gene HEAT repeat containing 5A Neighboring gene uncharacterized LOC134479124 Neighboring gene D-aminoacyl-tRNA deacylase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CircHECTD1 promoted MIRI-associated inflammation via inhibiting miR-138-5p and upregulating ROCK2. Yang YN, et al. Kaohsiung J Med Sci, 2023 Jul. PMID 37096660
    2. Hectd1 regulates intracellular localization and secretion of Hsp90 to control cellular behavior of the cranial mesenchyme. Sarkar AA, et al. J Cell Biol, 2012 Mar 19. PMID 22431752, Free PMC Article
    3. The Hectd1 ubiquitin ligase is required for development of the head mesenchyme and neural tube closure. Zohn IE, et al. Dev Biol, 2007 Jun 1. PMID 17442300, Free PMC Article
    4. Hectd1 is required for development of the junctional zone of the placenta. Sarkar AA, et al. Dev Biol, 2014 Aug 15. PMID 24855001, Free PMC Article
    5. A phenotype-based screen for embryonic lethal mutations in the mouse. Kasarskis A, et al. Proc Natl Acad Sci U S A, 1998 Jun 23. PMID 9636176, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircHECTD1 promoted MIRI-associated inflammation via inhibiting miR-138-5p and upregulating ROCK2.
      Title: CircHECTD1 promoted MIRI-associated inflammation via inhibiting miR-138-5p and upregulating ROCK2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within aorta development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic placenta development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart valve development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within natural killer cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural tube closure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neural tube closure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spongiotrophoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within trophoblast giant cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ventricular septum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HECTD1
    Names
    HECT domain containing 1
    HECT domain containing E3 ubiquitin protein ligase 1
    NP_001406767.1
    NP_001406768.1
    NP_001406769.1
    XP_006240149.1
    XP_038969108.1
    XP_063118174.1
    XP_063118175.1
    XP_063118176.1
    XP_063118177.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419838.1 → NP_001406767.1  E3 ubiquitin-protein ligase HECTD1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      D3ZLS5
      Related
      ENSRNOP00000008459.7, ENSRNOT00000008459.9

    2. NM_001419839.1 → NP_001406768.1  E3 ubiquitin-protein ligase HECTD1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    3. NM_001419840.1 → NP_001406769.1  E3 ubiquitin-protein ligase HECTD1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZNU0
      Related
      ENSRNOP00000079874.1, ENSRNOT00000108705.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      74916803..75003408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262104.1 → XP_063118174.1  E3 ubiquitin-protein ligase HECTD1 isoform X3

    2. XM_039113180.2 → XP_038969108.1  E3 ubiquitin-protein ligase HECTD1 isoform X1

      Conserved Domains (6) summary
      cd00078
      Location:2130 → 2607
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1276 → 1334
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1106 → 1239
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam12796
      Location:366 → 457
      Ank_2; Ankyrin repeats (3 copies)
      pfam18410
      Location:1891 → 1964
      BTHB; Basic tilted helix bundle domain

    3. XM_063262105.1 → XP_063118175.1  E3 ubiquitin-protein ligase HECTD1 isoform X4

    4. XM_063262107.1 → XP_063118177.1  E3 ubiquitin-protein ligase HECTD1 isoform X6

    5. XM_063262106.1 → XP_063118176.1  E3 ubiquitin-protein ligase HECTD1 isoform X5

    6. XM_006240087.4 → XP_006240149.1  E3 ubiquitin-protein ligase HECTD1 isoform X2

      Conserved Domains (7) summary
      smart00119
      Location:2153 → 2605
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:2129 → 2606
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00204
      Location:369 → 479
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam06701
      Location:1277 → 1335
      MIB_HERC2; Mib_herc2
      pfam12796
      Location:366 → 457
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      cl23730
      Location:1107 → 1240
      F5_F8_type_C; F5/8 type C domain
    Nucleotide Protein Strain
    Heading Accession and Version

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