Immp2l inner mitochondrial membrane peptidase subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Immp2lprovided by RGD
Full Name: inner mitochondrial membrane peptidase subunit 2provided by RGD
Primary source: RGD:2323665
See related: EnsemblRapid:ENSRNOG00000067070 AllianceGenome:RGD:2323665
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable peptidase activity. Predicted to be involved in signal peptide processing. Predicted to act upstream of or within several processes, including cerebellum vasculature development; ovulation; and protein processing involved in protein targeting to mitochondrion. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial inner membrane peptidase complex. Orthologous to human IMMP2L (inner mitochondrial membrane peptidase subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 64.1), Heart (RPKM 57.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (63797189..64696906)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (58070035..58970165)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (60958351..61859457)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493077

AI853880 (e-PCR)
- UniSTS:164495

D6Got74 (e-PCR)
- UniSTS:113814

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within blood circulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebellum vasculature development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrial respiratory chain complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ovarian follicle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ovulation	ISO Inferred from Sequence Orthology more info
involved_in protein processing involved in protein targeting to mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein processing involved in protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within respiratory electron transport chain	ISO Inferred from Sequence Orthology more info
involved_in signal peptide processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within superoxide metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of mitochondrial inner membrane peptidase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial inner membrane peptidase complex	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: mitochondrial inner membrane protease subunit 2

Names: IMP2 inner mitochondrial membrane peptidase-like; rCG61688-like

NP_001385633.1

EC 3.4.21.-

XP_038934060.1

EC 3.4.21.-

XP_038934061.1

EC 3.4.21.-

XP_038934062.1

EC 3.4.21.-

XP_038934063.1

EC 3.4.21.-

XP_038934065.1

EC 3.4.21.-

XP_063117436.1

EC 3.4.21.-

XP_063117437.1

EC 3.4.21.-

XP_063117438.1

EC 3.4.21.-

XP_063117439.1

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398704.1 → NP_001385633.1 mitochondrial inner membrane protease subunit 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6A7I6, A6HBE0

Conserved Domains (1) summary

cd06530
Location:36 → 146

S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

63797189..64696906

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078133.2 → XP_038934061.1 mitochondrial inner membrane protease subunit 2 isoform X1

Related

ENSRNOP00000088187.2, ENSRNOT00000098533.2

Conserved Domains (1) summary

cd06530
Location:36 → 99

S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...
XM_063261368.1 → XP_063117438.1 mitochondrial inner membrane protease subunit 2 isoform X2

UniProtKB/TrEMBL

A0A8I6A7I6, A6HBE0
XM_039078135.2 → XP_038934063.1 mitochondrial inner membrane protease subunit 2 isoform X1

Conserved Domains (1) summary

cd06530
Location:36 → 99

S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...
XM_039078134.2 → XP_038934062.1 mitochondrial inner membrane protease subunit 2 isoform X1

Conserved Domains (1) summary

cd06530
Location:36 → 99

S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...
XM_039078132.2 → XP_038934060.1 mitochondrial inner membrane protease subunit 2 isoform X1

Conserved Domains (1) summary

cd06530
Location:36 → 99

S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...
XM_063261369.1 → XP_063117439.1 mitochondrial inner membrane protease subunit 2 isoform X3
XM_039078137.2 → XP_038934065.1 mitochondrial inner membrane protease subunit 2 isoform X1

Conserved Domains (1) summary

cd06530
Location:36 → 99

S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...
XM_063261366.1 → XP_063117436.1 mitochondrial inner membrane protease subunit 2 isoform X2

UniProtKB/TrEMBL

A0A8I6A7I6, A6HBE0

Related

ENSRNOP00000102398.1, ENSRNOT00000171385.1
XM_063261367.1 → XP_063117437.1 mitochondrial inner membrane protease subunit 2 isoform X2

UniProtKB/TrEMBL

A0A8I6A7I6, A6HBE0

Related

ENSRNOP00000104080.1, ENSRNOT00000139681.1