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    Rnf41 ring finger protein 41 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362814, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rnf41provided by RGD
    Official Full Name
    ring finger protein 41provided by RGD
    Primary source
    RGD:1309557
    See related
    EnsemblRapid:ENSRNOG00000086706 AllianceGenome:RGD:1309557
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including identical protein binding activity; signaling receptor binding activity; and small GTPase binding activity. Predicted to be involved in several processes, including extrinsic apoptotic signaling pathway; positive regulation of reactive oxygen species metabolic process; and protein autoubiquitination. Predicted to act upstream of or within several processes, including negative regulation of mitophagy; regulation of hemopoiesis; and regulation of intracellular signal transduction. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in endoplasmic reticulum tubular network. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human RNF41 (ring finger protein 41). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 159.5), Adrenal (RPKM 132.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnf41 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1422651..1461700)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (838160..876869)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2827242..2854230)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 52 Neighboring gene solute carrier family 39 member 5 Neighboring gene small nucleolar RNA SNORA79 Neighboring gene nucleic acid binding protein 2 Neighboring gene small nucleolar RNA SNORA55 Neighboring gene transfer RNA serine (anticodon CGA) 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nrdp1 is involved in hippocampus apoptosis in cardiopulmonary bypass-induced cognitive dysfunction via the regulation of ErbB3 protein levels. Zheng J, et al. Int J Mol Med, 2019 Apr. PMID 30720051, Free PMC Article
    2. Transcriptional Effects of E3 Ligase Nrdp1 on Hypertrophy in Neonatal Rat Cardiomyocytes by Microarray and Integrated Gene Network Analysis. Zhang Y, et al. Cardiology, 2016. PMID 27428330
    3. Nrdp1 is Associated with Neuronal Apoptosis in Lipopolysaccharide-Induced Neuroinflammation. Shen J, et al. Neurochem Res, 2015 May. PMID 25896295
    4. Role of the Nrdp1 in Brain Injury Induced by Chronic Intermittent Hypoxia in Rats via Regulating the Protein Levels of ErbB3. Zhu J, et al. Neurotox Res, 2020 Jun. PMID 32200526
    5. Association between RNF41 gene c.-206 T > A genetic polymorphism and risk of congenital heart diseases in the Chinese Mongolian population. Zhang Y, et al. Genet Mol Res, 2016 Jun 17. PMID 27323192

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of the Nrdp1 in Brain Injury Induced by Chronic Intermittent Hypoxia in Rats via Regulating the Protein Levels of ErbB3.
      Title: Role of the Nrdp1 in Brain Injury Induced by Chronic Intermittent Hypoxia in Rats via Regulating the Protein Levels of ErbB3.
    2. Nrdp1 serves an important role in regulating the apoptosis induced by cardiopulmonary bypass in vivo and in vitro through regulating ErbB3 and phosphoAKT protein levels.
      Title: Nrdp1 is involved in hippocampus apoptosis in cardiopulmonary bypass-induced cognitive dysfunction via the regulation of ErbB3 protein levels.
    3. Pathway network analysis identified myocardial metabolism, DNA replication, and the cell cycle as the most important pathways targeted by Nrdp1.
      Title: Transcriptional Effects of E3 Ligase Nrdp1 on Hypertrophy in Neonatal Rat Cardiomyocytes by Microarray and Integrated Gene Network Analysis.
    4. The expression of Rnf41 was significantly increased in the cerebral cortex in a neuroinflammation model.
      Title: Nrdp1 is Associated with Neuronal Apoptosis in Lipopolysaccharide-Induced Neuroinflammation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables erythropoietin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-3 receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of mitophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of lymphocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum tubular network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum tubular network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase NRDP1
    NP_001012195.1
    NP_001387996.1
    NP_001387997.1
    NP_001387998.1
    XP_006240838.1
    XP_038935300.1
    XP_038935301.1
    XP_038935303.1
    XP_038935304.1
    XP_038935305.1
    XP_063119773.1
    XP_063119774.1
    XP_063119775.1
    XP_063119776.1
    XP_063119777.1
    XP_063119778.1
    XP_063119779.1
    XP_063119780.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012195.1 → NP_001012195.1  E3 ubiquitin-protein ligase NRDP1 isoform 2

      See identical proteins and their annotated locations for NP_001012195.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083614
      UniProtKB/TrEMBL
      A0A0G2K4P8, A0A8J8XH25
      Related
      ENSRNOP00000105032.1, ENSRNOT00000141904.1
      Conserved Domains (2) summary
      pfam08941
      Location:117 → 295
      USP8_interact; USP8 interacting
      cl17238
      Location:15 → 37
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. NM_001401067.1 → NP_001387996.1  E3 ubiquitin-protein ligase NRDP1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6KSD2, G3V930, Q5XIR0

    3. NM_001401068.1 → NP_001387997.1  E3 ubiquitin-protein ligase NRDP1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6KSD2, G3V930, Q5XIR0

    4. NM_001401069.1 → NP_001387998.1  E3 ubiquitin-protein ligase NRDP1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6KSD2, G3V930, Q5XIR0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      1422651..1461700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079375.2 → XP_038935303.1  E3 ubiquitin-protein ligase NRDP1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K4P8, A0A8J8XH25
      Conserved Domains (2) summary
      pfam08941
      Location:117 → 295
      USP8_interact; USP8 interacting
      cl17238
      Location:15 → 37
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_063263706.1 → XP_063119776.1  E3 ubiquitin-protein ligase NRDP1 isoform X1

      UniProtKB/TrEMBL
      A6KSD2, G3V930, Q5XIR0

    3. XM_006240776.5 → XP_006240838.1  E3 ubiquitin-protein ligase NRDP1 isoform X1

      See identical proteins and their annotated locations for XP_006240838.1

      UniProtKB/TrEMBL
      A0A0G2K4P8, A6KSD2, G3V930, Q5XIR0
      Related
      ENSRNOP00000034376.5, ENSRNOT00000029778.6
      Conserved Domains (2) summary
      cd16634
      Location:15 → 57
      mRING-HC-C3HC3D_Nrdp1; Modified RING finger, HC subclass (C3HC3D-type), found in neuregulin receptor degradation protein-1 (Nrdp1) and similar proteins
      pfam08941
      Location:137 → 315
      USP8_interact; USP8 interacting

    4. XM_063263705.1 → XP_063119775.1  E3 ubiquitin-protein ligase NRDP1 isoform X1

      UniProtKB/TrEMBL
      A6KSD2, G3V930, Q5XIR0

    5. XM_063263708.1 → XP_063119778.1  E3 ubiquitin-protein ligase NRDP1 isoform X2

      UniProtKB/TrEMBL
      A0A8J8XH25

    6. XM_039079373.2 → XP_038935301.1  E3 ubiquitin-protein ligase NRDP1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4P8, A6KSD2, G3V930, Q5XIR0
      Conserved Domains (2) summary
      cd16634
      Location:15 → 57
      mRING-HC-C3HC3D_Nrdp1; Modified RING finger, HC subclass (C3HC3D-type), found in neuregulin receptor degradation protein-1 (Nrdp1) and similar proteins
      pfam08941
      Location:137 → 315
      USP8_interact; USP8 interacting

    7. XM_039079372.2 → XP_038935300.1  E3 ubiquitin-protein ligase NRDP1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4P8, A6KSD2, G3V930, Q5XIR0
      Conserved Domains (2) summary
      cd16634
      Location:15 → 57
      mRING-HC-C3HC3D_Nrdp1; Modified RING finger, HC subclass (C3HC3D-type), found in neuregulin receptor degradation protein-1 (Nrdp1) and similar proteins
      pfam08941
      Location:137 → 315
      USP8_interact; USP8 interacting

    8. XM_063263709.1 → XP_063119779.1  E3 ubiquitin-protein ligase NRDP1 isoform X2

      UniProtKB/TrEMBL
      A0A8J8XH25

    9. XM_063263704.1 → XP_063119774.1  E3 ubiquitin-protein ligase NRDP1 isoform X1

      UniProtKB/TrEMBL
      A6KSD2, G3V930, Q5XIR0

    10. XM_063263710.1 → XP_063119780.1  E3 ubiquitin-protein ligase NRDP1 isoform X2

      UniProtKB/TrEMBL
      A0A8J8XH25

    11. XM_063263707.1 → XP_063119777.1  E3 ubiquitin-protein ligase NRDP1 isoform X2

      UniProtKB/TrEMBL
      A0A8J8XH25

    12. XM_063263703.1 → XP_063119773.1  E3 ubiquitin-protein ligase NRDP1 isoform X1

      UniProtKB/TrEMBL
      A6KSD2, G3V930, Q5XIR0

    13. XM_039079376.2 → XP_038935304.1  E3 ubiquitin-protein ligase NRDP1 isoform X3

      Conserved Domains (1) summary
      pfam08941
      Location:14 → 192
      USP8_interact; USP8 interacting

    14. XM_039079377.2 → XP_038935305.1  E3 ubiquitin-protein ligase NRDP1 isoform X3

      Conserved Domains (1) summary
      pfam08941
      Location:14 → 192
      USP8_interact; USP8 interacting
    Nucleotide Protein Strain
    Heading Accession and Version

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