Tpt1 tumor protein, translationally-controlled 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tpt1provided by MGI
Official Full Name: tumor protein, translationally-controlled 1provided by MGI
Primary source: MGI:MGI:104890
See related: Ensembl:ENSMUSG00000060126 AllianceGenome:MGI:104890
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Trt; p21; p23; TCTP
Summary: Enables DNA-binding transcription factor binding activity. Involved in negative regulation of ectoderm development and stem cell population maintenance. Located in nucleoplasm. Is expressed in cerebral cortex ventricular layer; cortical plate; sciatic nerve; and testis. Orthologous to several human genes including TPT1 (tumor protein, translationally-controlled 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 1476.1), bladder adult (RPKM 983.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D3; 14 40.29 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (76082771..76085743)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (75845256..75848303)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TPT1 Supports Proliferation of Neural Stem/Progenitor Cells and Brain Tumor Initiating Cells Regulated by Macrophage Migration Inhibitory Factor (MIF).
Title: TPT1 Supports Proliferation of Neural Stem/Progenitor Cells and Brain Tumor Initiating Cells Regulated by Macrophage Migration Inhibitory Factor (MIF).
Translationally Controlled Tumor Protein-Mediated Stabilization of Host Antiapoptotic Protein MCL-1 Is Critical for Establishment of Infection by Intramacrophage Parasite Leishmania donovani.
Title: Translationally Controlled Tumor Protein-Mediated Stabilization of Host Antiapoptotic Protein MCL-1 Is Critical for Establishment of Infection by Intramacrophage Parasite Leishmania donovani.
TCTP overexpression reverses age-associated telomere attrition by upregulating telomerase activity in mouse oocytes.
Title: TCTP overexpression reverses age-associated telomere attrition by upregulating telomerase activity in mouse oocytes.
Blockade of translationally controlled tumor protein attenuated the aggressiveness of fibroblast-like synoviocytes and ameliorated collagen-induced arthritis.
Title: Blockade of translationally controlled tumor protein attenuated the aggressiveness of fibroblast-like synoviocytes and ameliorated collagen-induced arthritis.
Overexpression of translationally controlled tumor protein ameliorates metabolic imbalance and increases energy expenditure in mice.
Title: Overexpression of translationally controlled tumor protein ameliorates metabolic imbalance and increases energy expenditure in mice.
TCTP is Essential for Cell Proliferation and Survival during CNS Development.
Title: TCTP is Essential for Cell Proliferation and Survival during CNS Development.
Translationally controlled tumor protein promotes liver regeneration by activating mTORC2/AKT signaling.
Title: Translationally controlled tumor protein promotes liver regeneration by activating mTORC2/AKT signaling.
The biological effects of Na,K-ATPase and TCTP interaction are reviewed.
Title: Some Biological Consequences of the Inhibition of Na,K-ATPase by Translationally Controlled Tumor Protein (TCTP).
that TPT1 knockdown altered the BECN1 interactome, a representative MTOR-independent pathway, to stimulate autophagosome formation
Title: TPT1 (tumor protein, translationally-controlled 1) negatively regulates autophagy through the BECN1 interactome and an MTORC1-mediated pathway.
The first crystal structure of murine HRF to 4.0A resolution, reveals a conserved fold. A model for the role of murine HRF in mast cell activation was created based on the human HRF structure.
Title: Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trt (e-PCR), detects polymorphism
- UniSTS:144688

PMC134017P1 (e-PCR)
- UniSTS:270716

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of ectoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	HDA more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed
located_in multivesicular body	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: translationally-controlled tumor protein

Names: 21 kDa polypeptide under translational control; fortilin; translationally regulated transcript (21 kDa)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001424592.1 → NP_001411521.1 translationally-controlled tumor protein isoform 2

Status: VALIDATED

Source sequence(s)

AC140244
NM_009429.4 → NP_033455.1 translationally-controlled tumor protein isoform 1

See identical proteins and their annotated locations for NP_033455.1

Status: VALIDATED

Source sequence(s)

AC140244

Consensus CDS

CCDS36980.1

UniProtKB/Swiss-Prot

P14701, P63028, Q3TMT0, Q3TWS8, Q3TWX0, Q3UAG7, Q569M9

UniProtKB/TrEMBL

D3YU75

Related

ENSMUSP00000106519.3, ENSMUST00000110894.9

Conserved Domains (1) summary

pfam00838
Location:1 → 167

TCTP; Translationally controlled tumor protein