Acat1 acetyl-CoA acetyltransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acat1provided by RGD
Official Full Name: acetyl-CoA acetyltransferase 1provided by RGD
Primary source: RGD:2016
See related: EnsemblRapid:ENSRNOG00000007862 AllianceGenome:RGD:2016
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RATACAL
Summary: Enables several functions, including acetyl-CoA C-acetyltransferase activity; coenzyme A binding activity; and identical protein binding activity. Involved in several processes, including adipose tissue development; liver development; and metanephric proximal convoluted tubule development. Located in mitochondrial matrix. Biomarker of end stage renal disease and nephrotic syndrome. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 1952.7), Kidney (RPKM 1300.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (62876003..62905080, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (53979813..54008861, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (58166990..58195884, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

rats treated with KD (EXP2) showed a significant down-regulated expression of ZnT-3, MT-3, ApoE, clusterin, and ACAT-1 in hippocampus
Title: Neurobehavioral Deficits in a Rat Model of Recurrent Neonatal Seizures Are Prevented by a Ketogenic Diet and Correlate with Hippocampal Zinc/Lipid Transporter Signals.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Acat1 (e-PCR), detects polymorphism
- UniSTS:547401

RH133398 (e-PCR)
- UniSTS:216681

RH141136 (e-PCR)
- UniSTS:223132

RH128334 (e-PCR)
- UniSTS:211642

BE116581 (e-PCR)
- UniSTS:248507

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables C-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acetyl-CoA C-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA C-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetyl-CoA C-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acetyl-CoA C-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables cholesterol O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables coenzyme A binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables potassium ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acetyl-CoA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in acetyl-CoA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in adipose tissue development	IEP Inferred from Expression Pattern more info	PubMed
involved_in coenzyme A biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in coenzyme A metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in isoleucine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ketone body catabolic process	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in metanephric proximal convoluted tubule development	IEP Inferred from Expression Pattern more info	PubMed
involved_in propionyl-CoA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
NOT located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: acetyl-CoA acetyltransferase, mitochondrial

Names: acetoacetyl-CoA thiolase; acetyl-Co A acetyltransferase 1 mitochondrial; acetyl-coenzyme A acetyltransferase 1

NP_058771.2

EC 2.3.1.9

XP_063121006.1

EC 2.3.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017075.2 → NP_058771.2 acetyl-CoA acetyltransferase, mitochondrial precursor

See identical proteins and their annotated locations for NP_058771.2

Status: VALIDATED

Source sequence(s)

FM065829, FM071064, FM098848, JAXUCZ010000008

UniProtKB/Swiss-Prot

P17764

UniProtKB/TrEMBL

A0A8I5Y5Z3, A6J4J7

Related

ENSRNOP00000010573.3, ENSRNOT00000010573.7

Conserved Domains (2) summary

PLN02644
Location:38 → 424

PLN02644; acetyl-CoA C-acetyltransferase

cd00751
Location:40 → 423

thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...